Thirty one patients with biologic and clinical diagnosis of hyperparathyroidism were submitted to thalium-technetium scan prior to exploration of the neck. Scan findings were compared with the pathologic results. Surgical exploration of the neck showed a parathyroid adenoma in 24 patients, parathyroid carcinoma in one patient, normal parathyroid in another patient and parathyroid hyperplasia in...

the mechanism of the genesis and development of obesity is not yet known. in particular, it is not known whether the main reason is and increase in energetic efficiency, i.e. better utilization of food consumed, or hyperplasia. this study was undertaken to throw some light on this subject. obesity was produced by chemical methods, i.e. by injections of gold-thioglucose and mono-sodium glutamate...

Although malignant melanoma (MM) is mainly a sporadic disease, about 3 to 15% of the cases may show familial aggregation [1, 2]. The diagnosis of melanoma in different members of the same families does indeed suggest there is a genetically-based hereditary predisposi‐ tion in a significant percentage of the cases. However, this predisposition has proven to be genetically heterogeneous. Only two...

Even-skipped (Eve) is a transcriptional repressor involved in segment formation in Drosophila melano-gaster. In order to gain further insights into the mechanism of action of Eve we tested whether it would function as a transcriptional repressor in mammalian cells. We found that Eve was indeed a potent repressor in two different mammalian cell types and at several promoters. In vitro transcript...

In this study the clinical and epidemiological characteristics of congenital adrenal hyperplasia were evaluated prospectively in 47 patients admitted in Imam Reza Hospital in Mashhad during a 4 year period. 21-hydroxylase deficiency was present in 42 patients (89.3%), the simple virilizing form in 6 and the salt-losing form in 36 of them. 11b hydroxylase deficiency was present in 5 patient...

Incidence of melanoma is steadily rising worldwide [1]. Lifetime risk of developing melano‐ ma in Caucasians is estimated as 1 in 50 individuals [2-3]. The incidence of melanoma varies according to the geographical origins of the population and the extent of sun exposure. In Australia and United States, an incidence of melanoma higher than observed in the Europe‐ an countries (with the notable ...

Cover image: A three-dimensional representation of the interaction universe of biological macromolecules and low molecular weight compounds. Each red sphere represents a chemical sub-space of macromolecules and each gray sphere corresponds to a chemical sub-space of ligands. Lines indicate multiple macromolecule-ligand interactions. Proteochemometric models describe interaction universe mathema...

Ultraviolet (UV) irradiation is a risk factor for development of malignant melanoma. UVA-induced lysosomal exocytosis and subsequent cell growth enhancement was studied in malignant melanoma cell lines and human skin melanocytes. UVA irradiation caused plasma membrane damage that was rapidly repaired by calcium-dependent lysosomal exocytosis. Lysosomal content was released into the culture medi...