The condition characterized by elevated gonadotrophins (gonadotropins elevated into the menopausal range), low sex steroids, and menstrual disorders was previously termed Premature Ovarian Failure (POF). However, over the last two years an effort has been made by many authors to have the term Primary Ovarian Insufficiency (POI) exclusively applied. Irrespective of the term, the condition concer...

INTRODUCTION Abetalipoproteinemia is a rare inherited disorder characterized by very low plasma levels of cholesterol and triglycerides, secondary to a dramatic decrease in apolipoprotein B-containing lipoproteins, which is induced by a mutation in the microsomal triglyceride transfer protein gene. CASE In our paper, we describe an atypical clinical manifestation of this condition in a young ...

We report on ovarian dysfunction in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). A gonadotropin releasing hormone test showed hyperresponses of luteinizing hormone (<0.2-->7.2 mIU/ml) and follicle-stimulating hormone (7.1-->44.8 mIU/ml), and a human menopause gonadotropin test yielded no estradiol response (13-->11 pg/ml). The results suggest that pr...

The case report describes the of 16-year-old girl who came to pediatric-gynecologist's for primary amenorrhea. She was normal height 155 cm, with female external genitalia, secondary sexual characteristics according Tanner M2,A3,Ph 4. In ultrasound we detected uterus infantile type, without endometrium, ovaries not visualized. functional cytology only basal and para-basal cells. As part differe...

There is evidence in the literature about more frequent association of vitiligo with autoimmune endocrine diseases (AEDs) compared to general population. No full-fledged studies aimed at assessing prevalence AEDs Russian cohort adult patients have been conducted. The study was assess patients. Patients monitored two clinics, Endocrinology Research Centre (Clinic 1; n = 39) and Moscow Scientific...