We read with interest the paper by Rabinowitz et al.' Our own impressions were at variance with his figures. To verify our views we analysed 33 cases of acute gastroenteritis treated within our hospital in the last six months. All patients admitted with acute gastroenteritis have urea and electrolytes determinations before treatment is started. In our laboratory, blood glucose estimation is per...

OBJECTIVES Community-acquired pneumonia is associated with a significant long-term mortality after initial recovery. It has been acknowledged that additional research is urgently needed to examine the contributors to this long-term mortality. The objective of the present study was to assess whether diabetes or newly discovered hyperglycaemia during pneumonia affects long-term mortality. DESIG...

Hyperglycaemia and convulsions in patients taking nalidixic acid are usually associated with overdosage of the drug or an underlying epileptic tendency.' :1 Nalidixic acid may also interfere with biochemical determinations of plasma and urinary glucose, giving falsepositive results. We describe an otherwise healthy patient who had convulsions and hyperglycaemia (confirmed by a glucose-specific ...

Physiological hyperglycaemia and hyperinsulinaemia are strong modulators of gene expression, which underpins some of their well-known effects on insulin action and energy metabolism. The aim of the present study was to examine whether acute in vivo exposure of healthy humans to hyperinsulinaemia and hyperglycaemia have independent or additive effects on expression of key metabolic genes in skel...

In response to oral glucose, glucagon-like peptide-1 receptor (Glp1r) knockout (Glp1r−/−) mice become hyperglycaemic due to impaired insulin secretion. Exercise also induces hyperglycaemia in Glp1r−/− mice. In contrast to oral glucose, exercise decreases insulin secretion. This implies that exercise-induced hyperglycaemia in Glp1r−/− mice results from the loss of a non-insulinotropic effect med...

Sir, Hypoglycaemia is a well-recognised feature of paracetamol overdose, after the development of fulminant hepatic failure, but we are aware of only one previous description of hyperglycaemia and that was in a patient with a family history of diabetes mellitus.' Over recent months we have seen five patients, all male, aged 17 to 40, who have had random blood sugars of 7.2-12.8 mmol/l (mean 9.1...

Dear Sir, The association between focal seizures and hyperglycaemia was first reported in 19651. The disorder is characterized by hyperglycaemia, no ketoacidosis, full consciousness (or minimal depression of sensorium) and focal seizures. We report 21 patients, who presented with seizures and nonketotic hyperglycaemia (NKH). This is a large case series. The aim of this report is to study clinic...