Diabetic retinopathy (DR), a major microvascular complication of diabetes, leads to retinal vascular leakage, neuronal dysfunction, and apoptosis within the retina. In this study, we combined STZ with whole-body hypoxia (10% O2) for quicker induction of early-stage retinopathy in C57BL/6 mice. We also compared the effects of a high glucose condition combined with hypoxia (1% O2) to a low glucos...

PURPOSE To report the characteristics of confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia (type 2 IMT). METHODS In a prospective observational cross-sectional study, both eyes of 33 patients with type 2 IMT were examined by means of fundus biomicroscopy, fundus photography, fluorescein angiography, and optical coherence tomography (OCT). Confocal blue reflectance ...

BACKGROUND Literature reports on ophthalmological manifestations related to tularemia, a zoonose caused by the bacterium Francisella tularensis, largely refer to Parinaud's oculoglandular syndrome, which consists of the association of conjunctivitis with preauricular lymphadenitis. In this paper, we report a case of intraocular inflammation during tularemia infection. CASE PRESENTATION A 52-y...

Manuscript received: 06.03.17; Revision accepted: 23.05.17 A 39‐year‐old female presented with gradual diminution of vision in her both eyes. She had been diagnosed with choroidal neovascularization (CNV) in the left eye in past and had received three anti‐vascular endothelial growth factor (anti‐VEGF) injections. Best‐corrected visual acuity was 20/60 in both eyes. Anterior segment examination...

Purpose Ocriplasmin is effective in closing macular holes due to vitreomacular traction. We present a case of macular subretinal material deposition observed with spectral-domain optical coherence tomography (SD-OCT) and multimodal imaging, following successful closure of a macular hole following intravitreal ocriplasmin injection. Observations An 81-year-old male presented with decreased vis...

AIM Transplant chorioretinopathy is a rare complication following solid organ or bone marrow transplantation and can result in severe vision loss. This series presents electroretinogram (ERG) results in patients with this condition. METHODS Patients who presented with bilateral vision loss following bone marrow or solid organ transplantation were identified. A complete ophthalmologic examinat...

PURPOSE To develop a computer-assisted method for the quantitation of choroidal neovascularization (CNV) for the support of clinical trials. METHODS Fluorescein angiographic images were selected from 5 patients enrolled in a clinical trial for which three follow-up visits were available. Thirty- and 600-second images were digitized at 1000 dots/in and registered (aligned) with polynomial warp...

Purpose. To report unusual presentation of type 1A idiopathic macular telangiectasia (IMT). Methods. Two middle-aged women with bilateral IMT were examined. Results. Both patients presented with a gradual vision loss in both eyes. Fundus examination was unremarkable in one case and showed small macular telangiectasia in both eyes in the other case. Fluorescein angiography (FA) revealed early bi...

an ERM and CNV on initial examination. However, the results of a fundus examination in our patients did not reveal any clinical signs of CNV before ERM surgery. In addition, 1 patient (case 2) underwent FA 1 month after ERM removal, which showed no hyperfluorescence in the macula. We do not believe FA is necessary before performing ERM removal to rule out preexisting CNV. However, FA is valuabl...