The mechanism of reactive hyperemia remains unknown. We hypothesized that reactive hyperemia was related to the opening of ATP-sensitive potassium channels during coronary occlusion. The resulting hyperpolarization of the smooth muscle cell plasma membrane might reduce calcium influx through voltage-dependent calcium channels and result in relaxation of smooth muscle tone and vasodilation. In e...

BURTON, K.. S., AND P. C. JOHNSON. Reactive hyperemia in individual capillaries of skeletal muscle. Am. J. Physiol. 223 (3) : 517-524. 1972.-Red cell velocity profiles in individual capillaries were studied in the sartorius muscle of the cat during reactive hyperemia using a dual-slit photometric system. The velocity profiles varied considerably from each other and from the simultaneously measu...

BACKGROUND Measurements of Doppler derived coronary flow reserve (CFR) and pressure derived fractional flow reserve (FFR) for coronary stenosis assessment depend on the induction of maximal hyperemia. Adenosine is the most widely used pharmacological agent but is expensive and poorly tolerated by some patients. METHODS AND RESULTS The objective of this study was to test the equivalency of ade...

UNLABELLED Impaired nitric oxide (NO)-dependent endothelial function is associated with the development of cardiovascular diseases. We hypothesized that erythrocyte levels of nitrosylated hemoglobin (HbNO-heme) may reflect vascular endothelial function in vivo. We developed a modified subtraction method using Electron Paramagnetic Resonance (EPR) spectroscopy to identify the 5-coordinate α-HbNO...

PURPOSE To assess the effect of single versus multiple subconjunctival ranibizumab injections in patients with an early pterygium recurrence. SETTING Single-center, academic practice. STUDY POPULATION Nine patients with early pterygium recurrence. OBSERVATIONAL PROCEDURE Subconjunctival ranibizumab (0.5 mg/0.05 mL) was administered adjacent to pterygium recurrence. Group 1 (n = 5) receive...

Since the description of the classical cardiovascular risk factors by the Framingham group some 50 years ago,1 more recent efforts have explored the utility of biomarkers to further refine risk stratification. Although vascular imaging and biochemical markers have shown considerable promise,2 assessment of vascular function has particular appeal. Endothelial dysfunction is an attendant feature ...

A 1.5-year-old female, hunting dog and a 6-year-old male crossbred presenting with eye discharge, conjunctival hyperemia swelling were reported in this study.After local anesthetic drug was administered, oph-thalmological examination revealed variable degree of ocular blepharospasm, hyperemia, the presence movable parasites hidden behind third eyelid membrane. total 15 (5 males, 10 fe-males) re...