Objective To assess stiff person syndrome (SPS) misdiagnosis and identify factors differentiating SPS from non-SPS. Background is a heterogeneous immune-mediated central hyperexcitability disorder that challenging to differentiate alternative diagnoses. Design/Methods Patients referred the Mayo Autoimmune Neurology Clinic for (01-Jul-2016 30-Jun-2021) were included. diagnosis was defined as com...

Hyperekplexia is a neurological disorder associated primarily with mutations in the α1 subunit of glycine receptors (GlyRs) that lead to dysfunction of glycinergic inhibitory transmission. To date, most of the identified mutations result in disruption of surface expression or altered channel properties of α1-containing GlyRs. Little evidence has emerged to support an involvement of allosteric G...

BACKGROUND AND PURPOSE Spasticity is a disabling complication of stroke and different noninvasive treatments are used to reduce muscle hypertonia. Shock waves are defined as a sequence of single sonic pulses largely used in the treatment of diseases involving bone and tendon as well as muscular contractures. The effect and duration of extracorporeal shock wave therapy (ESWT) was investigated on...