Background: Studies have revealed that polycystic ovary syndrome (PCOS) usually begins in adolescence, and it might manifest differently in different populations. In Iran, prevalence and phenotypes of PCOS among women in the community are unknown. The aim of the study was to estimate prevalence and clinical characteristics of Polycystic Ovary Syndrome in a community setting in Iran in 2013-2014...

Some testosterone-producing adrenal tumors can be successfully treated with long-acting GnRH analogs and adrenal venous sampling can be useful to detect rare ectopic sex steroid-producing tumors or confirm bilateral adrenal androgen hyperproduction in female hyperandrogenism.

Polycystic ovary syndrome (PCOS) is a disease that currently affects many women of reproductive age. In recent years, the incidence PCOS has increased, affecting 4% all worldwide, with prevalence 6% in Mexico. condition characterized by different metabolic, and hormonal disorders such as hyperandrogenism, chronic anovulation, menorrhagia or infertility. Patients commonly develop clinical altera...

Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by Mullerian duct aplasia in an XX individual with female phenotype presenting primary amenorrhea at adolescence. Multiple abnormalities may be associated with the MRKH syndrome. Genetic investigations focused on the genes of anti-Mullerian hormone and its receptor, as well as on Wt1, Pax2, Cftr and Hox genes, have been unproductiv...

Background. Excess adiposity and premature adrenarche (PA) are risk factors for the development of polycystic ovary syndrome (PCOS). Methods. Girls with slowly progressive precocious breast development, who were overweight and had PA (SPPOPA, 6.2-8.2 years, n = 5), overweight PA (6.6-10.8 years, n = 7), and overweight premenarcheal controls (OW-PUB, 10.6-12.8 years, n = 8) underwent hormonal sl...

We describe an immunoradiometric assay for human intact proinsulin in serum. In this method, one monoclonal antibody, coated onto polyacrylamide beads, cross-reacts with proinsulins and insulin. A sandwich is formed with intact proinsulin, split (65-66) proinsulin, and des (64-65) proinsulin binding with an 125I-labeled monoclonal antibody specific for an epitope at the intact B-C junction of p...

Other rare ovarian causes of hyperandrogenism include gynandroblastoma, gonadoblastoma, ovarian carcinoid, surface epithelial tumors (Brenner tumor) and metastatic tumors [5]. These tumors are rare representing only 10% of all ovarian tumors. Tumoral cause of hyperandrogenism is suspected when the serum testosterone levels are significantly elevated (>200 ng/ml), rapidly progressive symptoms of...

Polycystic ovary syndrome (POS) is one of the most common endocrine abnormalities affecting women of reproductive age. It is a cause of significant social embarrassment and emotional distress. The pathogenesis of the disease is not yet fully understood, but it is thought to be a complex multigenic disorder, including abnormalities in the hypothalamic-pituitary axis, steroidogenesis, and insulin...

Hypothesis / aims of study Androgens and anabolic steroids increase muscle mass and strength in general [1]. Due to the characteristics of hyperandrogenism in PCOS, it is plausible that women with PCOS may have increased muscle mass compared with controls [1]. The hyperandrogenism may lead to improve muscle function including pelvic floor muscle (PFM). In a recent study we found that women with...