The inhibitory neurotransmitter !-aminobutyric acid (GABA) has multiple receptors. In mammals, the GABAA receptor subtype is modulated by neurosteroids. However, whether steroid interaction with the GABAA receptor is unique to mammals or a conserved feature in vertebrates is unknown. Thus, neurosteroid modulation of the GABAA receptor was investigated in the brain of the bullfrog (Rana catesbei...

From Department of Biochemistry and Molecular Biology, Center for Brain Research 1 , Medical University of Vienna, Vienna, Austria 1 . Ecolé Normale Supérieure, Institut de Biologie de l’Ecole Normale Supérieure (IBENS) Paris France; Inserm U1024, Paris France; CNRS UMR8197, 75005 Paris, France 2 . Running Title: GABAA and P2X2 receptor interaction Address correspondence to: Isabella Sarto-Jack...

Tracazolate, a pyrazolopyridine, is an anxiolytic known to interact with -aminobutyric acid (GABA)A receptors, adenosine receptors, and phosphodiesterases. Its anxiolytic effect is thought to be via its interaction with GABAA receptors. We now report the first detailed pharmacological study examining the effects of tracazolate on a range of recombinant GABAA receptors expressed in Xenopus laevi...

OBJECTIVE There is evidence from animal studies that fluoxetine may enhance the concentrations of neuroactive steroids. Therefore, the authors investigated whether clinically effective treatment with antidepressants may alter the concentrations of neuroactive steroids in patients suffering from a major depressive episode. METHOD In the first study, eight drug-naive outpatients with major depr...

Nigerian Anacarddiacea family was investigated in this study on the account of their inherent structures with a view to bringing fore those features that could facilitate identification towards proper utilization based wood quality. Mature species Lannea grandis, welwitchii, Mangifera indica, Nothospondis staudtia, Pseudospondias microcarpa, Sclerocarya burrea, Sorindeia trimeris, Spondias mang...

Plant products provide a vast source of therapeutics, but not without toxicity. This study evaluated the in vitro cytotoxic and proliferative activity selected plant extracts on human peripheral blood mononuclear cells (PBMCs). The PBMCs from healthy donors were exposed to varying concentrations (25 µg/ml, 50 100 µg/ml 200 µg/ml) aqueous young leaves Mangifera indica (MI) stem barks Commiphora ...

Sixty-seven crude ethanol extracts from 50 plants (31 families), which are used in North Côte-d'Ivoire as traditional remedies for bacterial diseases, were screened for in vitro activity against Gram negative (Escherichia coli and Pseudomonas aeruginosa) and Gram positive (Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes and Bacillus subtilis) bacteria. Thirty-one extracts s...