background: the goal of this investigation was to compare the behavioral and physiological effects of three sedative drug regimens: oral meperidine (om), submucosal meperidine (sm) and oral midazolam (m) in healthy pediatric patients. materials and methods: this study sample consisted of thirty children aged 24-72 months (mean = 41.1) exhibiting definitely negative behavior. three sedative regi...

PURPOSE The purpose of this study was to compare the safety and efficacy of submucosal-administered meperidine (SM) and oral-administered meperidine (OM). Both regimens were used in conjunction with oral hydroxyzine for the sedation of children for dental treatment. METHODS Twenty preschool-age children, with previous histories of uncooperative behavior, were randomly assigned to first receiv...

Hydroxyzine, a piperazine H1-receptor antagonists effective in generalized anxiety disorder. Two simple, rapid, reliable, precise and accurate and cost-effective non-aqueous titrimetric procedures have been developed for the determination of hydroxyzine dihydrochloride (HDH) in bulk drug and its pharmaceutical formulations. The methods are based on the titration of the drug in glacial acetic ac...

PURPOSE This study proposes to complete declarative studies by describing the prescriptions of anxiolytics, hypnotics, and antidepressants dispensed to adolescents in a French region in 2002. METHODS This cross-sectional study analyzes all the hypnotic, anxiolytic, and antidepressant prescriptions (ATC codes beginning with N05B, N05C, and N06A, respectively) sent by adolescents (aged 13-17 ye...

Schinus terebinthifolius Raddi (Anacardiaceae), popularly known as red aroeira, is used in traditional medicine to treat inflammatory, gastric, and respiratory disorders. The aim of this study was to evaluate the antihistaminic activity of S. terebinthifolius (St) bark extract by using in vivo and in vitro experimental models. The effects of St were investigated on contractions induced by hista...

The aim of this study was to compare both the behavioral and physiological effects of 2 drug regimens in children: chloral hydrate (CH), meperidine (M), and hydroxyzine (H) (regimen A) versus midazolam (MZ), M, and H (regimen B). Patients between 24 and 54 months of age were examined by crossover study design. Behavior was analyzed objectively by the North Carolina Behavior Rating System and su...

BACKGROUND The H1-antihistamine cetirizine, a piperazine derivative widely used in daily practice, is rarely the cause of cutaneous drug reaction. Nevertheless, four cases of fixed drug eruption (FDE) as a result of this drug have been described recently. We present the case of a 45-year-old woman with a multilocalized FDE following oral intake of cetirizine for allergic rhinitis. METHODS Pat...

OBJECTIVES Transcranial direct current stimulation (tDCS)-induced erythema (skin reddening) has been described as an adverse effect that can harm blinding integrity in sham-controlled designs. To tackle this issue, we investigated whether the use of topical pretreatments could decrease erythema and other adverse effects associated with tDCS. MATERIALS AND METHODS Thirty healthy volunteers wer...