17beta-hydroxysteroid dehydrogenase type 7 (17beta-HSD7) is a novel estrogenic hydroxysteroid dehydrogenase from mammals. We modeled the three-dimensional structure of human 17beta-HSD7, analyzed the phylogeny of 17beta-HSD7 homologues and determined its expression pattern by in silico Northern blotting. Predominant expression is found not only in reproductive tissues (breast, ovary, placenta) ...

Japanese monkey liver contains multiple forms of dihydrodiol dehydrogenase with 3(20)alpha-hydroxysteroid dehydrogenase activity. Here we have purified the major and minor forms (DD1 and DD4) of the enzyme from Cynomolgus monkey liver, and isolated cDNA species for the two enzyme forms by reverse transcription-PCR. The cDNAs encoded proteins comprising of 323 amino acids, in which the sequence ...

It has been suggested that 20 -hydroxysteroid dehydrogenase (20 -HSD) is a T-cell differentiation marker in mice. In the human, this enzyme has generally been associated with types 1 and 2 17 -HSDs, which belong to the short-chain alcohol dehydrogenase family, whereas the rat, rabbit, pig and bovine 20 -HSDs are members of the aldoketo reductase superfamily, which also includes the 3 -HSD famil...

Background: Polycystic ovary syndrome (PCOS) is multifaceted and includes reproductive, metabolic, and general health disorders, so employing different animal models is needed to study the syndrome. Use of an aromatase inhibitor, letrozole, on adult female rats produces a phenotype remarkably similar to that of PCOS. Licorice has been used in treating women infertility for thousands of years. L...

Aim to determine the optimal tactics for examination and treatment of patients with macronadular bilateral adrenal hyperplasia.
 Material methods. The study included 11 macronodular hyperplasia (main group). To compare biochemical parameters, results 26 healthy people were studied (control group).
 Results. characterized by deficiency 11-hydroxylase, 21-hydroxylase, 11-hydroxysteroid ...

Background. Acne vulgaris belongs to androgen-dependent diseases where androgens cause sebaceous gland hypertrophy with a subsequent enlargement of sebum production.
 Aims. Determination the expression profile steroidogenesis-related proteins in normal skin and patients acne.
 Material methods. Immunohistochemical assay was carried out characterize TSPO, StAR, CYP11A1, 3-hydroxysteroi...