The objective of the present study was to prepare amorphous solid dispersion system simvastatin–hydroxypropylmethylcellulose (HPMC) to enhance the dissolution rate. Amorphous solid dispersion of simvastatin was prepared by solvent technique using HPMC as carrier with ratio of 1:1, 1:3 and 1:5 (w/w). Physicochemical properties of solid dispersions were investigated by X-ray powder diffraction, t...

Hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) are modified cellulose dietary fibers that generate viscous solutions in the gastrointestinal (GI) tract. This study assessed the effects of high viscosity (HV) HPMC, ultra-HV (UHV) HPMC, and medium viscosity MC on postprandial glucose and insulin responses in overweight and obese men and women (n = 50). After overnight fasts, subject...

The aim of this study was to develop new multi-layer matrix tablets to achieve bimodal drug release profiles (fast release/slow release/fast release). Hydroxypropyl methylcellulose acetate succinate (HPMCAS, type MF) was chosen as a matrix former, because it is water-insoluble at low, and water-soluble at high pH values. Studies focused on the elucidation of the drug release mechanisms from HPM...

Abstract Okra ( Abelmoschus esculentus ) has interesting nutritional and technological properties is naturally gluten-free (GF). This study investigated the physicochemical of okra powder obtained by a low-temperature drying process its impact on GF bread. Its potential synergy with other hydrocolloids (i.e., hydroxypropylmethylcellulose (HPMC) Psyllium fibre (Psy)) was also studied. As importa...

The interactions between proteins and polysaccharides are of considerable importance in the food industry. In this study, effect adding non-charged methylcellulose (MC), hydroxypropylmethylcellulose (HPMC), medium (GM) high (GH) molecular weight guar gum negatively charged sodium carboxymethylcellulose (CMC) was investigated on rheological thermal properties acid-swollen collagen pastes, as a f...

In this study, chocolate spreads were designed using oleogels with two oils (olive and sunflower), hydroxypropylmethylcellulose (HPMC) xanthan gum (XG), as structuring agents. Thus, the lipid profile of can be improved by totally or partially replacing coconut butter used in their preparation. Structural behaviour was analysed confocal laser scanning microscopy (CLSM), small amplitude oscillato...

Buccal matrices represent a widely accepted dosage form permitting convenient, easy, reliable drug administration and reducing errors. The aim of this study was the development mucoadhesive buccal for propranolol in children. Matrices were obtained by freeze-drying loaded polymeric solutions based on gum tragacanth (GT), pectin (PEC), hydroxypropylmethylcellulose (HPMC), sodium hyaluronate (HA)...