The purpose of this study was to examine the role of carotid sinus and cardiopulmonary mechanoreceptors in the reflex control of adrenal medullary catecholamine secretion. Afferent input from carotid sinus and cardiopulmonary mechanoreceptors was decreased by carotid occlusion or cervical vagal cold block, respectively. Increases in arterial pressure were significantly greater when either inter...

A selective and permanent destruction of sympathetic ganglia was achieved by injecting 6-hydroxydopamine in newborn animals. A lifelong chemical sympathectomy may thus be obtained. The process of cell damage and destruction is substantially different from that produced with an antiserum to a specific nerve growth factor.

A basic assumption of the 'rotational behavior model' is that amphetamine (AMPH) produces ipsiversive rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal dopamine (DA) system. However, we report here that if the normally 'dominant ' striatum is partially depleted of DA the majority of rats turn contraversive when given AMPH, i.e. in the opposite direction ...

Microinjections of the dopamine agonist apomorphine into the nucleus basalis prosencephali of pigeons elicit stereotyped pecking behaviour. Injections of 6-hydroxydopamine, a toxic dopamine antagonist, into the same nucleus impair stereotyped pecking induced by systemic apomorphine administration, but do not interfere with pecking in the normal feeding context.

Responses to vagal stimulation and acetylcholine were investigated in the feline pulmonary vascular bed under conditions of controlled pulmonary blood flow and constant left atrial pressure. Under baseline conditions, electrical stimulation of vagal efferent fibers increases lobar arterial pressure. However, when vasoconstrictor tone was increased, a depressor response was unmasked. The pressor...

Cardiac sympathetic denervation occurs commonly in Parkinson's disease. This study explored whether analogous denervation occurs in primates with Parkinsonism from systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). 6-[18F]Fluorodopamine positron emission tomographic scanning and plasma levels of catecholamines and their deaminated metabolites were used to assess sym...

Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle are used extensively as a model of Parkinson's disease. The present experiments sought to identify genes that were affected in the dopamine (DA)-denervated striatum after 6-hydroxydopamine-induced destruction of the nigrostriatal dopaminergic pathway in the rat. We also examined whether a single injection of methampheta...