It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing fluorescently labeled copolymers and hydrophobic fluorescent probes entrapped in the polymeric micelle core showe...

Hydrophobic membrane proteins are co-translationally targeted to the ER membrane, mediated by hydrophobic signal sequence. Mitochondrial membrane proteins escape this mechanism despite of the hydrophobic character. We examined sorting of membrane proteins into the mitochondria, using mitochondrial ABC transporter isoform (ABC-me). In the absence of 135-residue N-terminal hydrophilic segment (N1...

BackgroundPostoperative pericardial adhesion formation is a prominent cause of morbidity and death in cardiovascular surgery, but there still no ideal prevention method, especially redo cases. This study investigated novel antiadhesion trilaminar polymeric film compared with the Gore PRECLUDE Pericardial Membrane (W. L. & Associates, Flagstaff, AZ) negative control.MethodsOur membrane composed ...

Particle emissions into the atmosphere can cause extensive damage to environment and human health. To improve efficiency in collection of submicronic particles, new filtration media appeared on market due textile technologies equipment, such as filter developed with polytetrafluoroethylene (PTFE) membranes; however, these are more expensive. A coating technique called precoating is a economical...

A novel Janus membrane integrating an omniphobic substrate and an in-air hydrophilic, underwater superoleophobic skin layer was developed to enable membrane distillation (MD) to desalinate hypersaline brine with both hydrophobic foulants and amphiphilic wetting agents. Engineered to overcome the limitations of existing MD membranes, the Janus membrane has been shown to exhibit novel wetting pro...