نتایج جستجو برای: hydrophobic interactions

تعداد نتایج: 414086  

Journal: :Journal of immunology 2007
Andrea Ferrante Jack Gorski

Peptide binding to MHC class II (MHCII) molecules is stabilized by hydrophobic anchoring and hydrogen bond formation. We view peptide binding as a process in which the peptide folds into the binding groove and to some extent the groove folds around the peptide. Our previous observation of cooperativity when analyzing binding properties of peptides modified at side chains with medium to high sol...

Journal: :iranian journal of basic medical sciences 0
arezoo tahmourespour no 21, shahid salimian st., daneshgah av, azadi sq, esfahan, iran. ph.d student (islamic azad university tehran science & research branch) rooha kasra kermanshahi alzahra university of tehran, tehran, iran rasool salehi isfahan medical university, isfahan, iran abdolreza nabinejad agricultural research center, isfahan, iran

objective bacterial adhesion is governed by specific and nonspecific interactions such as hydrophobicity. hydrophobic interactions play a role in the adherence of microorganisms to a wide variety of surfaces and facilitate biofilm formation due to bacterial adhesion. in this article the relation between cell surface hydrophobicity and antibiotic resistance was studied. materials and methods we ...

2015
Meng Zhang River Charles Huimin Tong Lei Zhang Mili Patel Francis Wang Matthew J. Rames Amy Ren Kerry-Anne Rye Xiayang Qiu Douglas G. Johns M. Arthur Charles Gang Ren

Cholesteryl ester transfer protein (CETP) mediates the transfer of cholesterol esters (CE) from atheroprotective high-density lipoproteins (HDL) to atherogenic low-density lipoproteins (LDL). CETP inhibition has been regarded as a promising strategy for increasing HDL levels and subsequently reducing the risk of cardiovascular diseases (CVD). Although the crystal structure of CETP is known, lit...

2011
Anthony W. Fitzpatrick Tuomas P. J. Knowles Christopher A. Waudby Michele Vendruscolo Christopher M. Dobson

Identifying the forces that drive proteins to misfold and aggregate, rather than to fold into their functional states, is fundamental to our understanding of living systems and to our ability to combat protein deposition disorders such as Alzheimer's disease and the spongiform encephalopathies. We report here the finding that the balance between hydrophobic and hydrogen bonding interactions is ...

Journal: :The Journal of chemical physics 2014
Adam P Willard David Chandler

With molecular simulation for water and a tunable hydrophobic substrate, we apply the instantaneous interface construction [A. P. Willard and D. Chandler, "Instantaneous liquid interfaces," J. Phys. Chem. B 114, 1954-1958 (2010)] to examine the similarity between a water-vapor interface and a water-hydrophobic surface interface. We show that attractive interactions between a hydrophobic surface...

2015
Willard Adam Adam P. Willard David Chandler

The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. With molecular simulation for water and a tunable hydrophobic substrate, we apply the instantaneous interface construction [A.] to examine the similarity between a water-vapor interface and a water-hydrophobic surface interface. The intrinsic interface refers to molecular struc...

Journal: :Proteins 2005
Xiang Li Jie Liang

Characterizing multibody interactions of hydrophobic, polar, and ionizable residues in protein is important for understanding the stability of protein structures. We introduce a geometric model for quantifying 3-body interactions in native proteins. With this model, empirical propensity values for many types of 3-body interactions can be reliably estimated from a database of native protein stru...

Journal: :Chemical science 2014
RuoWen Wang Chunming Wang Yang Cao Zhi Zhu Chaoyong Yang Jianzhong Chen Feng-Ling Qing Weihong Tan

An artificial nucleic acid analogue capable of self-assembly into duplex merely through hydrophobic interactions is presented. The replacement of Watson-Crick hydrogen bonding with strictly hydrophobic interactions has the potential to confer new properties and facilitate the construction of complex DNA nanodevices. To study how the hydrophobic effect works during the self-assembly of nucleic a...

Journal: :Biophysical journal 2008
Tatiana K Rostovtseva Horia I Petrache Namdar Kazemi Elnaz Hassanzadeh Sergey M Bezrukov

Critical to biological processes such as secretion and transport, protein-lipid interactions within the membrane and at the membrane-water interface still raise many questions. Here we examine the role of lipid headgroups in these interactions by using gramicidin A (gA) channels in planar bilayers as a probe. We show that although headgroup demethylation from phosphatidylcholine (DOPC) to phosp...

2008
Sudhir Husale Wilfried Grange Marc Karle Stephan Bürgi Martin Hegner

The interaction of cationic surfactants with single dsDNA molecules has been studied using force-measuring optical tweezers. For hydrophobic chains of length 12 and greater, pulling experiments show characteristic features (e.g. hysteresis between the pulling and relaxation curves, force-plateau along the force curves), typical of a condensed phase (compaction of a long DNA into a micron-sized ...

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