Hairless mice were treated in vivo with empty phospholipid and ‘skin lipid’ liposomes, respectively. The deposition of a hydrophobic drug (hydrocortisone) and a hydrophilic drug (inulin) was investigated in both treated and untreated skin. It was found that drugs should be encapsulated in liposomes or at least be administered together with the lipid, to achieve targeted drug delivery. Pretreatm...

the objective of the present study was to design an oral controlled drug delivery system for sparingly soluble diclofenac sodium (dcl) using guar gum as triple-layer matrix tablets. matrix tablet granules containing 30% (d1), 40% (d2) or 50% (d3) of guar gum were prepared by the conventional wet granulation technique. matrix tablets of diclofenac sodium were prepared by compressing three layers...

in order to enhance in vitro dissolution and content uniformity of poorly soluble drug glimepiride by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using peg 6000 and pvp k25 (as carrier). eight batches (f1-f8) were prepared by factorial design (23) by taking three factors i.e. the concentration of: dr...

The water swelling and drug diffusion from initially hydrophilic, glassy polymer matrices were modeled using concentration-dependent diffusion equations for water and drug. The transport equation for water incorporated a relaxation-dependent mechanism. These equations were solved with an appropriate boundary condition incorporating a relaxation-dependent Deborah number. Experimental results fro...

The issues of solubility for the targeted drug delivery new affects, many existing drug. minimum 40% novel from pharmaceutical industries are showing poor ability solubilization in water. Hence to increase such waters and their bioavailabilities major challenges scientists. So overcome problems dissolution, development solid dispersion with carriers having good water is beneficiary. methods fou...

We describe design, synthesis, physico-chemical characterization and preliminary biological evaluation of micelle-forming polymer drug conjugates with controlled drug release intended for tumor treatment. The structure of the conjugates was designed to enable tumor tissueand cell-specific drug release and micelle disassembly to avoid side effects accompanying classic chemotherapy and guarantee ...

Delivery of drugs into eyes using conventional drug delivery systems, such as solutions, is a considerable challenge to the treatment of ocular diseases. Drug loss from the ocular surface by lachrymal fluid secretion, lachrymal fluid-eye barriers, and blood-ocular barriers are main obstacles. A number of ophthalmic drug delivery carriers have been made to improve the bioavailability and to prol...

Metformin HCL, the only available biguanide, remains the first line drug therapy for patients with Type 2 diabetes mellitus acts by decreasing hepatic glucose output and peripheral insulin resistance. It has relatively short plasma half life, low absolute bioavailability. The overall objective of the present work was to develop an oral sustained release metformin tablet prepared by direct compr...

the aim of the current study was to design a porous osmotic pump–based drug delivery system for controlling the release of buspirone from the delivery system. the osmotic pump was successfully developed using symmetric membrane coating. the core of the tablets was prepared by direct compression technique and coated using dip-coating technique. drug release from the osmotic system was studied us...

Glaucoma is a common progressive eye disorder and the treatment strategies will benefit from nanoparticulate delivery systems with high drug loading and sustained delivery of intraocular pressure lowering agents. Niosomes have been reported as a novel approach to improve drug low corneal penetration and bioavailability characteristics. Along with this, poor entrapment efficiency of hydrophilic ...