We established an in vitro assay for the addition of glycosyl-phosphatidylinositol (GPI) anchors to proteins using procyclic trypanosomes engineered to express GPI-anchored variant surface glycoprotein (VSG). The assay is based on the premise that small nucleophiles, such as hydrazine, can substitute for the GPI moiety and effect displacement of the membrane anchor of a GPI-anchored protein or ...

We have performed a density functional theory investigation on the structural and electronic properties of pristine and Nitrogen-doped TiO2 anatase nanoparticles as the adsorbents for removal and degradation of hydrazine molecules in the environment. We have presented the most stable adsorption configurations and examined the interaction of hydrazine molecule with these doped and undoped nanopa...

3-mercapto-1,2,4 benzotriazine (1) was methylated by methyl iodide in the presence of base to afford 1,2-dihydro-3-methyhercapto-1, 2,4 benzotriazine (2). the latter was reacted with hydrazine hydrate to give the corresponding 3-hydrazine derivative (3). compound (3) on condensation with phenacyl bromide gave 3- phenacyl hydrazino l,2,4-benzotriazine (4). ppa cyclization of the ketone (4) yield...

A novel series of nine indolyl pyrazoline pharmacophore were synthesized by the reaction of hydrazine hydrate derivatives with the synthesized chalcones (C4,C5,C6). The chalcones were synthesized by the Claisen Schimdt condensation method. These pyrazoline derivatives were evaluated for anti-inflammatory activity using Carrageenan induced paw oedema method. The activity profile reveals that the...

The reaction of 2-carboxy-benzaldehyde and hydrazine hydrate unexpectedly yielded the title compound, C(16)H(10)N(2)O(3), which comprises one phthalide ring, one phthalazine system and a chiral centre. The phthalide unit is almost perpendicular to the phthalazine system, forming a dihedral angle of 87.1 (3)°. The packing is governed by weak C-H⋯O hydrogen-bonding inter-actions, forming layers p...

In the title hydrated salt, C(16)H(12)Cl(2)N(3) (+)·Cl(-)·H(2)O, there is a small twist in the cation as seen in the torsion angle linking the benzene ring to the rest of the mol-ecule [171.96 (17)°]. In the crystal, the quinolinium H atom forms a hydrogen bond to the lattice water mol-ecule, which also forms hydrogen bonds to two Cl(-) anions. Each Cl(-) ion also accepts a hydrogen bond from t...

Neat 3,5-dinitro-1H-1,2,4-triazole was obtained in quantitative yield from potassium 3,5-dinitro-1,2,4-triazolate and sulfuric acid. The compound was purified by sublimation in vacuo at 110 °C. Pure HDNT is a hygroscopic white solid that is impact and friction sensitive and decomposes explosively upon heating to 170 °C. However, the presence of impurities might lower the decomposition temperatu...

The new 3,5-(substituted) pyrazoles and isoxazoles were prepared by reaction of (N'(1)E, N'(3)E)- N'(1), N'(3)-bis (3,4,5-substitutedbenzylidene)malonohydrazide with hydrazine hydrate and hydroxylamine hydrochloride respectively under solvothermal conditions involving an ecofriendly method without any environmental pollution, the yield are in the range of 75-96%. The structure of the new compou...

High quality graphenes were prepared from low-cost expandable graphite via a facile hydrazine hydrate or concentrated ammonia-assisted quenching strategy.