The RNA.DNA hybrid poly(rA).poly(dT) can adopt two conformations, depending upon its degree of hydration. Fibers yield a conventional A' RNA-like pattern at 79% relative humidity. In contrast, under highly solvated conditions this material yields an x-ray diffraction pattern with striking similarities to that of B DNA and clearly different from the RNA-like diffraction patterns previously obtai...

LDL cholesterol (LDL-C) is cleared from plasma via cellular uptake and internalization processes that are largely mediated by the low-density lipoprotein cholesterol receptor (LDL-R). LDL-R is targeted for lysosomal degradation by association with proprotein convertase subtilisin-kexin type 9 (PCSK9). Gain of function mutations in PCSK9 can result in excessive loss of receptors and dyslipidemia...

Tricalcium aluminate (C3A) is a major phase of Portland cement clinker and some dental root filling cements. An accurate all-atom force field is introduced to examine structural, surface, and hydration properties as well as organic interfaces to overcome challenges using current laboratory instrumentation. Molecular dynamics simulation demonstrates excellent agreement of computed structural, th...

Single crystal neutron diffraction is one of the powerful methods to obtain structure information, including that hydrogen atoms. The IBARAKI biological diffractometer called iBIX a high-performance time-of-flight single elucidate hydrogen, protonation and hydration structures macromolecules in various life processes. Most notably merit observation atoms states. From remarkable results by iBIX,...

Background: Cisplatin is an antineoplastic agent used to treat many malignancies; however, the main side effect of cisplatin is nephrotoxicity. The aim of this study was to evaluate the effect of hydration therapy with and without magnesium on prevention of cisplatin-induced nephrotoxicity. Methods: This retrospective study was performed on 46 patients with malignancy who were candidate to rec...

This article addresses the interplay between heat of hydration and physico-mechanical properties of calcium sulfate hemi-hydrate in the presence of retarding additives such as citric and malic acids and sodium citrate. The heat of hydration was measured using a semi-isothermal calorimeter. Results proved that citric and malic acids had superior impact on hydration and mechanical properties. Whi...

The hydration of SON68 glass (non-radioactive surrogate for R7T7 glass, the French industrial high-level radioactive waste management) was studied at between 30 and 70°C a relative humidity 95% period 6 months. thicknesses were shown to increase with temperature did not exceed few nanometres 50°C, or tens 70°C. dependence rates followed Arrhenius law enabled determination an activation energy. ...

abstract eating and drinking are essential for life. there are clinical situations that artificial hydration is necessary. for dying patients artificial hydration looks useless and in many conditions could even be harmful (e.g. pulmonary edema in hypoalbuminemic patients). in our medical culture artificial hydration is a symbol of care to the patient and withholding it, is a very emotive issue,...

this article addresses the interplay between heat of hydration and physico-mechanical properties of calcium sulfate hemi-hydrate in the presence of retarding additives such as citric and malic acids and sodium citrate. the heat of hydration was measured using a semi-isothermal calorimeter. results proved that citric and malic acids had superior impact on hydration and mechanical properties. whi...

Water has anomalous properties that emanate from its hydrogen-bond-induced structure. Most of the unique properties ofwater are related to the network of strong three-dimensional hydrogen bonds that interconnect the water molecules [1, 2]. According to Stillinger [3], water has a preferential three-dimensional tetrahedral structure containing a few free or single-bonded water molecules. A simul...