This study was undertaken to explore the effects of lymphatic blockage on the metabolism of hyaluronan in the skin. In initial experiments, PH] hyaluronan was injected subcutaneously into the tail skin of rats that either had no surgical intervention (control) or into those that had their lymphatic drainage blocked two hours earlier (acute lymphedema) or after the lymphatics had been blocked fo...

The extracellular matrix is composed of hyaluronan different molecular weights that play roles in cellular proliferation, migration, and differentiation. dysregulated accumulation alters the mechanical biochemical properties it associated with several pathological states. Biomaterials can be engineered using native backbone or chemically modified to target cells via specific receptors, such as ...

BACKGROUND Dimethylnitrosamine (DMN), a potent hepatotoxin, administered to rats, provides a convenient model for toxic liver injury. Indicators of early liver injury are important clinically, for surveillance, for screening new drugs that are potentially hepatotoxic and for identifying drugs that protect against liver injury. Both cirrhosis and wound healing culminate in deposition of fibrous ...

Hyaluronan is a biological polysaccharide that may exist in different degrees of polymerization. Several investigations reported that low molecular mass hyaluronan may have pro-inflammatory activity, while high molecular mass hyaluronan can exert beneficial effects. Starting from these data, the aim of this study was to investigate the effect of hyaluronan of different molecular mass in mouse a...

In 1988 a novel fermentation route to high molecular weight hyaluronan mediated by Streptococcus zooepidemicus was first reported. few years, following rapidly expanding demand for as key ingredient of facial dermal fillers, streptococcal production commercialized, in Western Europe and North America, subsequently China. Outlining the case microbial hyaluronan, an emergent technology bioeconomy...

This study was undertaken to explore the effects of lymphatic blockage on the metabolism of hyaluronan in the skin. In initial experiments, [3H] hyaluronan was injected subcutaneously into the tail skin of rats that either had no surgical intervention (control) or into those that had their lymphatic drainage blocked two hours earlier (acute lymphedema) or after the lymphatics had been blocked f...

Hyaluronan (hyaluronic acid) is a simple, nonantigenic, nonsulfated glycosaminoglycan present everywhere in the extracellular compartments of the body. Noteworthy, it is highly conserved phylogenetically, from sauropsida to mammals; and plays a plethora of roles from embryonic/fetal development to adult physiological and pathological events, including tumor development. In reproduction, hyaluro...

Hyaluronan is a naturally occurring polymer that has enjoyed wide successes in biomedical and cosmetic applications as coatings, matrices, and hydrogels. For controlled delivery applications, formulating native hyaluronan into microspheres could be advantageous but has been difficult to process unless organic solvents are used or hyaluronan has been modified by etherification. Therefore, we pre...

The localization of hyaluronan has been determined in tailbud stage embryos of Xenopus laevis using a neurocan-alkaline phosphatase fusion protein. This polysaccharide was located between the germ layers and enriched in mesenchyme, the lumen of the neural tube, the embryonic gut, the hepatic cavity and the heart. A full-length cDNA for a hyaluronan synthase, Xhas2 has been cloned. The expressio...

aims and objectives: the present study was carried to evaluate the adjunctive effect of the local application of hyaluronan gel to scaling and root planing in the treatment of chronic periodontitis. materials and methods: twelve patients with chronic periodontitis participated in the study with a split mouth design. plaque formation and bleeding on probing (bop) were evaluated pre-treatment (ba...