The human central nervous system (CNS) infections remain the leading cause of intensified morbidity and mortality rates around world. Vanquish barriers that protect brain from pathogens is a prerequisite to develop meningitis. commonest pathogens, pneumococcus, meningococcus, E. coli, H. influenzae are main causative agents in children adults; associated with high […]

Emerging and re-emerging pathogens present a huge challenge to human and veterinary medicine. Emergence is most commonly associated with ecological change, and specific risk factors are related to the type of pathogen, route of transmission and host range. The biological determinants of host range remain poorly understood but most pathogens can infect multiple hosts, and three-quarters of emerg...

  Antibiotics are the best known products of actinomycete. Over 5,000 antibiotics have been identified from the cultures of Gram positive and Gram-negative organisms, and filamentous fungi, but only about 100 antibiotics have commercially been used to treat human, animal and plant diseases. The genus, Streptomycete, is responsible for the formation of more than 60% of known antibiotics. Bacteri...

Since the rise of modern humans, changes in demography and land use and frequent contact with wildlife and domesticated animals have created ongoing opportunities for pathogen loss, gain, and evolution in the human population. Early transportation networks and population expansion created a world where many human-specific pathogens are now ubiquitous, yet zoonoses continue to emerge as humans e...

We report two Australian patients with soft tissue infections due to Photorhabdus species. Recognized as important insect pathogens, Photorhabdus spp. are bioluminescent gram-negative bacilli. Bacteria belonging to the genus are emerging as a cause of both localized soft tissue and disseminated infections in humans in the United States and Australia. The source of infection in humans remains un...

Fecal wastes from domestic animals, wildlife and humans are applied to the soil surface and to varying extents are incorporated into the soil. These fecal wastes can also enter water systems by direct contamination of the water or through seepage or surface runoff. Humans contaminate water sources through poorly processed sewage effluents, malfunctioning septic tanks and seepage from sanitary l...

Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental approaches based on high throughput cell cultures, which we have developed to interrogate human ...

Are pathogens in outdoor air a health issue at present or will they become a problem in the future? A working group called AirPath - Outdoor Environments and Human Pathogens in Air was set up in 2007 at University College London, UK with the aim of opening new discussion and creating a research network to investigate the science and impacts of outdoor pathogens. Our objective in this paper is t...

The spectrum of human pathogens and the infectious diseases they cause is continuously changing through evolution and changes in the way human populations interact with their environment and each other. New human pathogens most often emerge from an animal reservoir, emphasizing the central role that non-human reservoirs play in human infectious diseases. Pathogens may also re-emerge with new ch...