In the mammalian ovary a small number of follicles are steadily recruited from the quiescent pool to undergo development. Follicle loss, maintenance and growth are strictly controlled by complex molecular interactions including the phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) signalling pathway. Stimulation of PI3K promotes phosphorylation of Akt resulting in follicle survival and ac...

In themammalianovary a small numberof follicles are steadily recruited from thequiescent pool to undergodevelopment. Follicle loss, maintenance and growth are strictly controlled by complex molecular interactions including the phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) signalling pathway. Stimulation of PI3K promotes phosphorylation of Akt resulting in follicle survival and activat...

BACKGROUND Young female adult and adolescent cancer patients facing life-preserving but fertility-threatening chemo- or radiation-therapy are increasingly seeking options to protect their reproductive potential. Ovarian tissue cryopreservation with transplantation is a promising technique to safeguard fertility in cancer patients. However, this method may risk re-introduction of the original ca...

BACKGROUND Although transplantation of cryopreserved ovarian tissue is a promising approach to restore fertility in cancer patients, it is not advisable for women at risk of ovarian involvement due to the threat of reintroducing malignant cells. The aim of this study was therefore to find an alternative for these patients by development of an artificial ovary. METHODS For construction of the ...

Many young cancer patients are now being given the option to store ovarian cortical biopsies before undergoing potentially damaging chemo- or radiotherapy. This tissue mainly contains large numbers of immature primordial follicles. Currently the only option to restore fertility using this tissue is by transplantation which may not be a viable option for all patients. Greater options to realise ...

Background: DZN (diazinon) is an organophosphate insecticide that had been used in agriculture and for domestic and veterinary use for several years and caused many negative effects on plants and animal species, especially on human. The aim of present study was to evaluate the effects of DZN on MDA (malondialdehyde) and GSH (glutathione) levels in female rat reproductive tissue (ovary) and to...

background: the purpose of this study was to compare the three different strategies, intravenous (iv) hydroxylethyl starch (hes), iv human albumin (ha), and oral cabergoline (cb) in the prevention of ovarian hyperstimulation syndrome (ohss). materials and methods: in this prospective randomized clinical trial, 91 women at high risk of developing ohss were allocated into the three groups, group ...

Receptor for Advanced Glycation Endproducts (RAGE) is expressed in ovarian tissue and associated with ovarian carcinoma. With a radiolabeled anti-RAGE antibody, we proposed to show extent of RAGE expression in animal model and effect of blocking RAGE on ovarian cancer cell growth. Methods: We measured inhibition of p-Akt and p-stat3 in SKOV-3 human ovarian carcinoma cell line and measured cell ...

background: dzn (diazinon) is an organophosphate insecticide that had been used in agriculture and for domestic and veterinary use for several years and caused many negative effects on plants and animal species, especially on human. the aim of present study was to evaluate the effects of dzn on mda (malondialdehyde) and gsh (glutathione) levels in female rat reproductive tissue (ovary) and to a...