objectivemycophenolate mofetil (mmf) is commonly administered concomitantly with ganciclovir for managingtransplant recipients who infected with cmv. this study was conducted to evaluate the probable effects ofganciclovir on mycophenolic acid (mpa) pharmacokinetic.materials and methodsten kidney transplant recipients who full field inclusion and exclusion criterias enrolled in this study. thefi...

background: the innate immunity plays an important role in the host response to transplantation by toll-like receptors and results in development of acute allograft rejection. the aim of this study was to evaluate the association of tlr2 and cd14 (co-receptor) gene polymorphisms with acute rejection in kidney transplant recipients.   methods : the study was conducted in a population of 239 subj...

results the accuracy for detecting number of main renal arteries were not different in both groups which were 96.7% in ct angiography group and 90% in traditional angiography group (p = 0.15). the accuracy for detection of main renal veins were 100% in group 1 and 96.7% in group 2 (p = 0.31). patients and methods a total number of 60 living kidney donors who underwent open surgical approach for...

Mesenchymal Stromal Cells (MSCs) are tissue homeostatic and immune modulatory cells that have shown beneficial effects in kidney diseases and transplantation. Perivascular Stromal Cells (PSCs) share characteristics with bone marrow MSCs (bmMSCs). However, they also possess, most likely due to local imprinting, tissue-specific properties and play a role in local tissue homeostasis. This tissue s...

Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. Objective: To study microchimerism in a group of kidney transplant recipi...

background: kidney transplantation is the best alternative treatment for end-stage renal disease. several studies have been devoted to investigate predisposing factors of graft rejection. however, there is inconsistency between the results. the objective of the present study was to utilize an intuitive and robust approach for variable selection, random survival forests (rsf), and to identify im...

The purpose of this human study was to investigate the effect of oxygen pretreatment in living kidney donors on early renal function of transplanted kidney. Sixty living kidney donor individuals were assigned to receive either 8-10 L/min oxygen (Group I) by a non-rebreather mask with reservoir bag intermittently for one hour at four times (20, 16, 12, and 1 hours before transplantation) or air ...

Phosphate-buffered sucrose (PBSc) solution is effective for short-term hypothermic preservation of tissue during feline kidney transplantation. A high-molecular-weight polyethylene glycol (35,000 Da, PEG35) reportedly enhanced the protective effects against cold-induced tubular injuries in animal kidney transplantation models. We investigated the ability of PBSc solution containing PEG35 to pre...

The national demand for kidney transplantation far outweighs the supply of kidney organs. Currently, a patient's ability to receive a kidney transplant varies depending on where he or she seeks transplantation. This reality is in direct conflict with a federal mandate from the Department of Health and Human Services. We analyze current kidney allocation and develop an alternative kidney sharing...