نتایج جستجو برای: human itpa protein

تعداد نتایج: 2478083  

Journal: :Journal of viral hepatitis 2013
V Di Marco V Calvaruso S Grimaudo D Ferraro R M Pipitone R Di Stefano A Craxì

Genetic factors can influence the outcome of antiviral therapy in chronic hepatitis C (HCV). We evaluated the role of interleukin-28B single nucleotide polymorphisms (SNPs) and inosine triphosphatase (ITPA) gene variants in HCV cirrhosis treated with Peg-Interferon and ribavirin. A prospective cohort of 233 patients with compensated cirrhosis received 1-1.5 μg/kg/week of Peg-Interferon alpha-2b...

Journal: :Human molecular genetics 2011
Yasuhito Tanaka Masayuki Kurosaki Nao Nishida Masaya Sugiyama Kentaro Matsuura Naoya Sakamoto Nobuyuki Enomoto Hiroshi Yatsuhashi Shuhei Nishiguchi Keisuke Hino Shuhei Hige Yoshito Itoh Eiji Tanaka Satoshi Mochida Masao Honda Yoichi Hiasa Asako Koike Fuminaka Sugauchi Shuichi Kaneko Namiki Izumi Katsushi Tokunaga Masashi Mizokami

Hematologic abnormalities during current therapy with pegylated interferon and ribavirin (PEG-IFN/RBV) for chronic hepatitis C (CHC) often necessitate dose reduction and premature withdrawal from therapy. The aim of this study was to identify host factors associated with IFN-induced thrombocytopenia by genome-wide association study (GWAS). In the GWAS stage using 900K single-nucleotide polymorp...

Journal: :Hepatology 2011
Fumitaka Suzuki Yoshiyuki Suzuki Norio Akuta Hitomi Sezaki Miharu Hirakawa Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Satoshi Saito Yasuji Arase Kenji Ikeda Mariko Kobayashi Kazuaki Chayama Naoyuki Kamatani Yusuke Nakamura Yuzo Miyakawa Hiromitsu Kumada

UNLABELLED Polymorphisms of the inosine triphosphatase (ITPA) gene influence anemia during pegylated interferon (PEG-IFN) and ribavirin (RBV) therapy, but their effects during triple therapy with PEG-IFN, RBV, and telaprevir are not known. Triple therapy for 12 weeks, followed by PEG-IFN and RBV for 12 weeks, was given to 49 patients with RBV-sensitive (CC at rs1127354) and 12 with RBV-resistan...

2015
Raoel Maan Adriaan J. van der Meer Willem Pieter Brouwer Elisabeth P. C. Plompen Milan J. Sonneveld Robert Roomer Annemiek A. van der Eijk Zwier M. A. Groothuismink Bettina E. Hansen Bart J. Veldt Harry L. A. Janssen Andre Boonstra Robert J. de Knegt Chen-Hua Liu

BACKGROUND/OBJECTIVE Genetic polymorphisms in the inosine triphosphatase (ITPA) gene have been associated with the protection from early ribavirin(RBV)-induced hemolytic anemia among patients with chronic hepatitis C virus (HCV) infection. The aim of the present study was to investigate the association between the functional ITPA variants and hematological side effects during antiviral therapy ...

Journal: :hepatitis monthly 0
krzysztof domagalski department of infectious diseases and hepatology, nicolaus copernicus university, bydgoszcz, poland; department of plant physiology and biotechnology, nicolaus copernicus university, torun, poland małgorzata pawlowska department of infectious diseases and hepatology, nicolaus copernicus university, bydgoszcz, poland; department of infectious diseases and hepatology, nicolaus copernicus university, bydgoszcz, poland. tel/fax: +48-523255605 andrzej tretyn department of plant physiology and biotechnology, nicolaus copernicus university, torun, poland; centre for modern interdisciplinary technologies, nicolaus copernicus university, torun, poland waldemar halota department of infectious diseases and hepatology, nicolaus copernicus university, bydgoszcz, poland malgorzata tyczyno department of infectious diseases and hepatology, nicolaus copernicus university, bydgoszcz, poland dorota kozielewicz department of infectious diseases and hepatology, nicolaus copernicus university, bydgoszcz, poland

background three single nucleotide polymorphisms (snps) near interleukin-28b (il-28b) gene were shown to be highly associated with treatment response (svr) in patients with chronic hepatitis c virus (hcv) infection. there is limited data about the role of single and combined il-28b polymorphisms in hcv-infected polish population. objectives this study's aim was to determine predictability of th...

Journal: :hepatitis monthly 0
ning zhao department of infectious diseases, shengjing hospital, affiliated hospital of china medical university, shenyang, china xue-lian wang department of infectious diseases, shengjing hospital, affiliated hospital of china medical university, shenyang, china qiu-hong gu department of infectious diseases, shengjing hospital, affiliated hospital of china medical university, shenyang, china fen huang department of infectious diseases, shengjing hospital, affiliated hospital of china medical university, shenyang, china wei zheng department of pathophysiology, china medical university, shenyang, china zhi-wei li department of infectious diseases, shengjing hospital, affiliated hospital of china medical university, shenyang, china; corresponding author: zhi-wei li, department of infectious diseases, shengjing hospital, affiliated hospital of china medical university, 39 huaxiang road, 110022, shenyang, china. tel: +86-18940251727, fax: +86-2483956451, e-mail:

conclusions trim22 gene ring domain -364t/c polymorphism is associated with chronic hbv infection in chinese han population. results 243 (31.76%) of 765 chinese han patients showed genetic variation in the trim22 gene. trim22 snps were mainly in ring area -364t/c site, accounting for 98.35% of the population. there were no significant differences (p > 0.05) in the ring domain -364t/c snp and al...

Journal: :journal of research in medical sciences 0
maryam keshvari seyed moayed alavian bita behnava ali pouryasin heidar sharafi

background: a dinucleotide variant rs368234815 in interferon lambda 4 (ifnl4) gene was recently found to be associated with the hepatitis c virus (hcv) treatment response. this study aimed to assess the impact of ifnl4 rs368234815 polymorphism on treatment response to pegylated?ifn alpha (peg?ifn??) and ribavirin (rbv) in hemophilic patients with chronic hepatitis c (chc). materials and methods...

Journal: :iranian journal of immunology 0
iraj pakzad department of microbiology, ilam university of medical sciences, ilam abbas rezaee faculty of medical sciences, tarbiat modaress university, tehran mohammad javad rasaee faculty of medical sciences, tarbiat modaress university, tehran bahman tabbaraee department of bacterial vaccines, pasteur institute of iran, tehran ali delpisheh department of community medicine, ilam university of medical sciences, ilam, iran

background: the immunogenic brucella abortus ribosomal protein l7/l12 is a promising candidate antigen for the development of subunit vaccines against brucellosis. objective: this study was aimed to evaluate the protection of recombinant human serum albumin (has)-l7/l12 fusion protein in balb/c mice. methods: the amplified l7/l12 gene was cloned in pyhsa5 vector, pyhsa5-l7/l12 construct was tra...

Journal: :iranian journal of basic medical sciences 0
huang bin department of gynecology and obstetrics, shenzhen hospital of beijing university, shenzhen 518036, china wu ruifang department of gynecology and obstetrics, shenzhen hospital of beijing university, shenzhen 518036, china li ruizhen department of gynecology and obstetrics, shenzhen hospital of beijing university, shenzhen 518036, china liu zhihong department of gynecology and obstetrics, shenzhen hospital of beijing university, shenzhen 518036, china li juan department of gynecology and obstetrics, shenzhen hospital of beijing university, shenzhen 518036, china wang chun department of gynecology and obstetrics, shenzhen hospital of beijing university, shenzhen 518036, china

objective(s): to investigate the expression of human papilloma virus (hpv) l1 capsid protein, and human telomerase rna component (hterc) in cervical cancer and the role of detection of both genes in screening of cervical cancer.   materials and methods: a total of 309 patients were recruited and cervical exfoliated cells were collected. immunocytochemistry was employed to detect hpv l1 capsid p...

Journal: :archives of trauma research 0
ali kabir minimally invasive surgery research center, iran university of medical sciences, tehran, ir iran; department of epidemiology, faculty of public health, shahid beheshti university of medical sciences, tehran, ir iran; faculty of public health, shahid beheshti university of medical sciences, tehran, ir iran. tel: +98-2144471350, fax: +98-2144471349سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) mehrdad moghimi department of surgery, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) afshin amini department of toxicology and emergency medicine, faculty of medicine, imam hossein hospital, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

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