Previous studies have shown that mouse dermis is composed of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used a combination of comparative spatial transcriptional profiling of human and mouse dermis and single-cell transcriptional profiling of human dermal fibroblasts. We show that there are at least four distinct fibroblast pop...

Environmental microplastics exist at sub-micrometer sizes (nanoplastics, NPs) as they continue to disintegrate over time. Although concerns regarding harm human health are growing, data on the effects of NPs skin lacking. Therefore, this study sought investigate whether penetrate and affect physiology cells Different sized polystyrene (0.2, 0.5, 1.0 μm) (approximately sub-micron level) tagged w...

Deeper wrinkles and loss of elasticity are one the skin-aging symptoms. Collagen breakdown by matrix metalloproteinase-1 (MMP-1), which is induced reactive oxygen species (ROS) pro-inflammatory cytokines, has been known to be responsible for these Therefore, much attention paid chemicals suppress MMP-1 activity. Epigallocatechin-3-gallate (EGCG), catechin rich in green tea, reported show antiox...

The effects of human recombinant interleukin (IL)-1 beta on elastin gene expression were studied in human skin fibroblast cultures by Northern hybridization and transient transfection experiments. Incubation of the cells with IL-1 beta elevated the elastin mRNA steady-state levels by approximately 3- to 4-fold. A similar increase was noted at the protein level, when estimated by indirect immuno...

abstract background: chemotherapy by using agents such as etoposide is a common way for inhibition of tumors. this treatment is accompanied by many undesirable side effects. calprotectin is an abundant protein in the neutrophil cytosol, it has growth-inhibitory and apoptosis-inducing activities against various cell types such as tumor cells. in this study to introduce calprotectin as a suitable...

Functional foods to prevent aging, particularly skin have grown in popularity as society ages and science uncovers the pathological mechanisms of aging. In this study, we used processed ginseng, one famous functional foods, along with fermentation utilizing novel Aspergillus niger strain KHNT-1 enhance its value efficacy. We successfully produced fermented black ginseng (FBG) investigated anti-...

Little is known about miRNA decay, especially in skin wound healing. Here, by small RNA sequencing human and tissues, we identified 12 miRNAs that 5P:3P strand ratios significantly changed. To rule out the effects caused cellular composition, performed CD45- epidermal cells (mainly keratinocytes) CD90+ dermal (fibroblasts) isolated from wounds. Our results showed ratio of miR-X changed both cel...

Prolonged bleeding is a general complication that occurs after tooth extraction or oral surgery. Thus, patients must apply pressure and use absorbable wound dressings to stop prevent blood loss. This method stops causes clotting of blood. However, some people have disorders cannot with applied Therefore, haemostatic foam dressing an interesting material can be used without hindering in the site...