In this paper, we consider the design of large-scale multiple allocation hub-and-spoke transportation networks in a competitive environment. We adopt a generic hub arc location model that locates arcs with discounted transport costs connecting pairs of hub facilities. Two firms compete for customers in a Stackelberg framework where the leader firm locates hub arcs to maximize its revenue, given...

This study presents an optimal framework for the operation of integrated energy systems using demand response programs. The main goal of integrated energy systems is to optimally supply various demands using different energy carriers such as electricity, heating, and cooling. Considering the power market price, this work investigates the effects of multiple energy storage devices and demand res...

The hub location–allocation problem under uncertainty is a real-world task arising in the areas such as public and freight transportation and telecommunication systems. In many applications, the demand is considered as inexact because of the forecasting inaccuracies or human’s unpredictability. This study addresses the robust uncapacitated multiple allocation hub location problem with a set of ...

In this paper, we present a novel multi-objective mathematical model for capacitated single allocation hub location problem. There are the vehicle capacity constraint and capacity restrictions amount of the incoming flow to the hub while the balancing requirements of incoming quantities of flow to the each hub is considered. Moreover, there is a set of available capacities for each potential hu...

HLP (hub location problem) tries to find locations of hub facilities and assignment of nodes to extended facilities. Hubs are facilities to collect, arrange, and distribute commodities in telecommunication networks, cargo delivery systems, etc. Hubs are very crucial and their inaccessibility impresses on network whole levels. In this paper, first, total reliability of the network is defined bas...

Human clear cell renal cell carcinoma (ccRCC) is the most common solid lesion within kidney, and its prognostic is influenced by the progression covering a complex network of gene interactions. In our study, we screened differential expressed genes, and constructed protein-protein interaction (PPI) network and a weighted gene co-expression network to identify key genes and pathways associated w...

The p-hub center problem is to locate p hubs and to allocate non-hub nodes to hub nodes such that the maximum travel time (or distance) between any origin–destination pair is minimized. We address the p-hub center allocation problem, a subproblem of the location problem, where hub locations are given. We present complexity results and IP formulations for several versions of the problem. We esta...

In this study a hierarchical hub location problem with two layers is considered. The first layer includes small hubs and the second one includes a star-shaped network central hub. The considered case is a cargo delivery network where there is hierarchy between hubs. All the hubs and links are capacitated and there are three kinds of commodities for each of which there is a special kind of vehic...