BACKGROUND Hypertonic saline (HTS) has been previously demonstrated to have immune modulatory and vascular protective effects. We assessed the effect of donor pretreatment with HTS on allograft preservation in a porcine model of orthotopic heart transplantation. METHODS AND RESULTS Orthotopic transplants were performed after 6 hours of cold static allograft storage. Donor pigs were randomly a...

Background—Hypertonic saline (HTS) has been previously demonstrated to have immune modulatory and vascular protective effects. We assessed the effect of donor pretreatment with HTS on allograft preservation in a porcine model of orthotopic heart transplantation. Methods and Results—Orthotopic transplants were performed after 6 hours of cold static allograft storage. Donor pigs were randomly ass...

Background: High throughput sequencing (HTS) has become one of the primary experimental tools used to extract genomic information from biological samples. Bioinformatics tools are continuously being developed for the analysis of HTS data. Beyond some well-defined core analyses, such as quality control or genomic alignment, the consistent development of custom tools and the representation of seq...

The field of viral genomics and bioinformatics is experiencing a strong resurgence due to high-throughput sequencing (HTS) technology, which enables the rapid and cost-effective sequencing and subsequent assembly of large numbers of viral genomes. In addition, the unprecedented power of HTS technologies has enabled the analysis of intra-host viral diversity and quasispecies dynamics in relation...

High-throughput sequencing (HTS) has become a powerful tool for the detection of and sequence characterization of microRNAs (miRNA) and other small RNAs (sRNA). Unfortunately, the use of HTS data to determine the relative quantity of different miRNAs in a sample has been shown to be inconsistent with quantitative PCR and Northern Blot results. Several recent studies have concluded that the majo...

This paper presents a feasibility study of an offshore wind farm (OWF) HVDC integration system using high-temperature superconductor (HTS) DC cables. A representative ±100 kV/2 GW point-to-point OWF is proposed including HTS cables and two converter stations modular multilevel converters (MMCs). To be compatible with the high current rating cables, each onshore consists three MMCs in parallel. ...

Various types of mutation and editing (M/E) events in microRNAs (miRNAs) can change the stabilities of pre-miRNAs and/or complementarities between miRNAs and their targets. Small RNA (sRNA) high-throughput sequencing (HTS) profiles can contain many mutated and edited miRNAs. Systematic detection of miRNA mutation and editing sites from the huge volume of sRNA HTS profiles is computationally dif...

The discovery of the superconductivity phenomenon and understanding of electromagnetic properties of high temperature superconducting (HTS) materials allow the optimization and creation of several applications, such as, electrical machines and drives, fault current applications, or superconducting magnetic energy storage, well described in the literature. Electromechanical conversion devices ba...

Since the discovery of high temperature superconductors more than 2 decades ago, there has been interest in their use for future fusion machines. Lack of performance of commercially available materials, however, dampened the initial optimism. However, recent advances in HTS materials, mostly second-generation tapes, open attractive topologies. In addition to reduced cryogenic loads and increase...