A 50-year-old AIDS patient with a CD4 T-cell count of 114/mm(3) was admitted with cerebellar symptoms of left CN XI weakness, wide-based gait with left-sided dysmetria, abnormal heel-knee-shin test, and dysdiadochokinesia. MRI showed region of hyperintensity in the left inferior cerebellar hemisphere involving the cortex and underlying white matter. Serological tests for HSV1, HSV2, and syphili...

The Herpesviruses are important human pathogens that can cause mild to severe lifelong infections with high morbidity. Alternate drugs such as ayurvedic drugs are now a day’s used for management of HSV infections due to the emergence of resistant strains.The aqueous and methanol extract from leaves of Justicia adhatoda, were used to study the cytotoxicity effect on Vero cell line by using MTT a...

Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii). thymidine and SO(4) and the bisubstrate analogs, (iii). TP(4)A, and (iv). TP(5)A have been solved. Additionally, the structure of herpes simplex virus type-1 thymidine kinase (HSV1-TK) in complex with TP(5)A has been determined. These are the first structures of nucleoside ki...

In this study, we synthesized Tc(CO)3-2 0-aminomethylpyridyl-20-deoxyuridine (Tc(CO)3-AMPDU) and Tc(CO)3-aminoethylpyridyl-20-deoxyuridine (Tc(CO)3-AEPDU) as potential agents for imaging the expression of the non-invasive herpes simplex virus type-1 thymidine kinase. AMPDU and AEPDU were synthesized from uridine in five chemical steps and then labeled with [Tc(CO)3(H2O)3] + (370MBq/0.5mL) at 10...

Alzheimer's disease (AD) is a neurodegenerative affecting ~50 million people worldwide. To date, there no cure and current therapies have not been effective in delaying progression. Therefore, an urgent need for better understanding of the pathogenesis AD to rethink possible therapies. Herpes simplex virus type 1 (HSV1) has recently received growing attention its potential role sporadic AD. The...

Human brain cells were examined for the presence of herpes simplex virus type 1 (HSV1) DNA sequences by in situ hybridisation. Viral genome was detected in immunosuppressed patients with virological evidence of past HSV infection but not in immunosuppressed patients with no such evidence. In patients who had not been immunosuppressed, no HSV DNA sequences were detectable.

Front Cover. A new C-nucleoside with strongly pairing ethynylmethylpyridone base and 3'-azido-2',3'-dideoxyribose sugar dubbed 'AZW' was described. The image shows the structure of AZW against a backdrop AZT in dotted cloud representation. nucleoside inhibitory activity Herpes simplex virus type 1 (HSV1) as reported by Richert et al. their full paper at10.1002/cbdv.202000937.