The Hippo signaling pathway regulates organ size and tissue homeostasis from Drosophila to mammals. Central to this pathway is a kinase cascade wherein Hippo (Hpo), in complex with Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein, known as the YAP coactivator in mammalian cells. The FERM domain proteins Merlin (M...

BACKGROUND Patients who present for steroid injections are not routinely screened for potential hypothalamic-pituitary-adrenal (HPA) axis suppression from previous steroid exposure. Patients often receive various steroid therapies that are not reported by the patient or recorded in available medical records. Yet, HPA axis suppression has been reported with a single intra-articular injection. ...

Cholestatic patients often present with clinical features suggestive of adrenal insufficiency. In the bile duct-ligated (BDL) model of cholestasis, the hypothalamic-pituitary-adrenal (HPA) axis is suppressed. The consequences of this suppression on cholangiocyte proliferation are unknown. We evaluated 1) HPA axis activity in various rat models of cholestasis and 2) effects of HPA axis modulatio...

Coordination of organ growth during development is required to generate fit individuals with fixed proportions. We recently identified Drosophila Dilp8 as a key hormone in coupling organ growth with animal maturation. In addition, dilp8 mutant flies exhibit elevated fluctuating asymmetry (FA) demonstrating a function for Dilp8 in ensuring developmental stability. The signals regulating Dilp8 ac...

As a new approach, the acidity that wood exhibits under moderate conditions is assayed by stimulated dissociation of weak wood acids in lightly basic secondary phosphate solutions. To assure a sufficient dissociation of hardly soluble weak acids in the solution, the amount of wood suspended in Na(2)HPO(4) solutions should be small but vary depending on the degree of acidity of wood species. How...

objective(s) the mechanism(s) by which antidepressants regulate the hypothalamic-pituitary-adrenal (hpa) axis remain elusive. the endocannabinoid system (ecbs) which exhibits antidepressant potential, appears to regulate the hpa axis activity. therefore, we aimed to investigate the role of the ecbs in the action of doxepin including its effect on the hpa axis. materials and methods male wistar ...

Volume 61, no. 11, p. 4022, column 2, line 10: "K(inf2)HSO(inf4)" and "KH(inf2)SO(inf4)" should read "K(inf2)HPO(inf4)" and "KH(inf2)PO(inf4)," respectively. Line 13: "K(inf2)HSO(inf4)" should read "K(inf2)HPO(inf4)." Line 14: "KH(inf2)SO(inf4)" and "0.2 g of CaCO(inf3)" should read "KH(inf2)PO(inf4)" and "1 g of CaCO(inf3)," respectively. [This corrects the article on p. 4022 in vol. 61.].

The superconducting properties of Y1Ba2(Cu1−x Alx)3O7/Y2BaCuO5 bulk superconductors with different Al contents were studied (x = 0.0025–0.05). A peak effect was observed at intermediate magnetic fields over a wide temperature range below Tc. The influence of standard oxygenation (SO) at 400 ◦C and high pressure oxygenation (HPO) at 750 ◦C on the critical current density Jc was investigated. We ...

Coordination between cell proliferation and cell death is essential to maintain homeostasis in multicellular organisms. In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family kinase Warts (Wts; also called Lats). Hpo phosphorylates and activates Wts, which in turn, through unknown mechanisms, negatively regulates the transcri...

Employing achiral organic amines (2-methylbenzimidazole and 1,4-diazabicyclo[2.2.2]octane) as the structure-directing agent and ligand, two chiral zincophosphites, [Zn(C(8)H(8)N(2))(HPO(3))] 1 and (C(6)H(13)N(2))[Zn(3)(C(6)H(12)N(2))(HPO(3))(3)(H(2)PO(3))] 2, have been hydro(solvo)-thermally synthesized, crystallizing in the chiral space group P2(1)2(1)2(1). Single-crystal structural analysis r...