UNLABELLED Photodynamic therapy leads to oxidative stress through the generation of free radicals. Oxidative stress causes damage to cellular macromolecules such as nucleic acids, proteins and lipids. AIM To examine the hematoporphyrin derivative (HpD) - mediated photodynamic effect on cervical adenocarcinoma cell line HeLa. METHODS The HpD localization in HeLa cells was analyzed by confoca...

Hazelnuts are rich in monounsaturated fatty acids and antioxidant bioactive substances: their consumption has been associated with a decreased risk of cardiovascular disease events. A systematic review and a meta-analysis was performed to combine the results from several trials and to estimate the pooled (overall) effect of hazelnuts on blood lipids and body weight outcomes. Specifically, a Bay...

A general solution to the positive ion feedback problem in Hybrid Photon Detectors (HPD), photo multipliers (PM) and other similar detectors was found in the insertion of a permanent electrostatic potential barrier which prevents drift of positive ions from the anode, or the first dynode, towards the photocathode. In this paper we present the method as applied to the Intevac HPD.

To select bronchial epithelial BEAS-2B cell line as control, cellular uptake and localization of Hematoporphyrin derivatives (HPD) were compared between normal cells (BEAS-2B), various lung cancer lines, well lines. Cellular HPD was quantified by fluorescence intensity with a multifunctional microplate reader flow cytometry. Laser scanning confocal microscopy used to observe compare the distrib...

Exact expressions for single and product moments of generalized order statistics are derived when the underlying population is assumed to have a Rayleigh distribution. Bayesian estimators and highest posterior density (HPD) credible intervals are obtained for the scale parameter and reliability function based on generalized order statistics. We also derive the Bayes predictive estimator and HPD...

(1) Background: To assess and compare speech intelligibility with conventional universal musician-specific hearing protection devices (HPD); (2) Methods: The sample comprised 15 normal-hearing musicians of both sexes who had been professionals for more than 5 years. They underwent thorough audiological assessment free-field audiometry to measure the attenuation levels three HPD models (musician...

The aim of this work was to evaluate the response in 10 generations of selection for ovulation rate in rabbits using a cryopreserved control population. Selection was based on the phenotypic value of ovulation rate estimated at d 12 of second gestation by laparoscopy. To produce the control population, embryos from 50 donor females and 18 males, belonging to the base generation of the line sele...

A gram-positive polychlorinated biphenyl (PCB) degrader, Rhodococcus sp. strain RHA1, metabolizes biphenyl through the 2-hydroxypenta-2,4-dienoate (HPD) and benzoate metabolic pathways. The HPD metabolic pathway genes, the HPD hydratase (bphE1), 4-hydroxy-2-oxovalerate aldolase (bphF1), and acetaldehyde dehydrogenase (acylating) (bphG) genes, were cloned from RHA1. The deduced amino acid sequen...

INTRODUCTION Hearing impairment remains the main occupational health problem in the manufacturing industry, and its contributing factors have not been well controlled. METHODS Unmatched case control and comparative studies were carried out among fertilizer factory workers in Sarawak with the aim of determining contributing factors for hearing impairment. Respondents consisted of 49 cases that...

Hematoporphyrin derivative (HpD) is a systemically administered photosensitizing agent that may be of value in the treatment of solid tumors. When corneal endothelial cells were perfused in the specular microscope with HpD and exposed to a 25-W incandescent light at 5 cm (5.5 mW/cm) there was anatomic disruption of corneal endothelial cells and swelling of the corneal stroma. Perfusion with 0.2...