Since use of antinociceptive chemical drugs for relief of pain have many side effects, medical plants seem very noticeable today. Previous findings indicate that Foeniculum vulgare (FV) modulates pain in both animal and human. The present work investigated the effects of Hydoalcoholic extract of FV on acute pain in Hot plate and Tail flick models. Albino mice (20-30 gr) were used for this study...

Since use of antinociceptive chemical drugs for relief of pain have many side effects, medical plants seem very noticeable today. Previous findings indicate that Foeniculum vulgare (FV) modulates pain in both animal and human. The present work investigated the effects of Hydoalcoholic extract of FV on acute pain in Hot plate and Tail flick models. Albino mice (20-30 gr) were used for this study...

The cooling of the steel strip in ROT (run out table) of the hot rolling process is very important in that the ROT is the final process to control the mechanical properties of the final products. In general the products are cooled by the circular water jets which makes the comparatively thick residual water layer about 100–200 mm with the supplied flow rate on the plate. The basic phenomenon go...

We used the hot plate test and the formalin test to evaluate the antinociception of choline after i.c.v. or i.v. administration. The analgesic mechanism of choline was also studied. The response latency of mice was significantly prolonged in the hot plate test after choline (90-120 mug/animals) i.c.v. administration in a dose-dependent manner. Pretreatment with methyllycaconitine citrate (MLA),...

Mitragynine (MG), a major alkaloidal constituent extracted from the plant Mitragyna speciosa Korth, is known to exert an opioid-like activity. Our previous study showed the involvement of opioid systems in the antinociceptive activity of MG in the tail-pinch and hot-plate tests in mice. In the present study, to clarify the opioid receptor subtypes involved in the antinociceptive action of MG, w...

AIM This paper is focused on the investigation the effects of two polymeric matrices for indomethacin in cutaneous pain models in mice. There were used two different co-polymers polyhydroxyethyl methacrylate and undecan, polymerization reactions being conducted under nitrogen, at 80 degrees C. MATERIAL AND METHODS The experiments were carried out on white Swiss mice (20-25 g), divided into 6 ...

AIM To investigate the involvement of L-type Ca(2+) channels in antinociceptive action induced by the 5-HT precursor, 5-hydroxytryptophan (5-HTP). METHODS Female Kunming mice were treated with either 5-HTP (20-80 mg/kg, ip) alone, or the combination of 5-HTP and fluoxetine (2-8 mg/kg, ip), pargyline (15-60 mg/kg, ip), nimodipine (2.5-10 mg/kg, ip), nifedipine (2.5-10 mg/kg, ip), verapamil (2....

Pleiotrophin (PTN) is a growth factor that exhibits neurotrophic actions and is upregulated at sites of nerve injury. Upregulation of PTN levels in injured dorsal root ganglion correlates with decreased mechanical allodynia and faster recovery from Chronic Constriction Injury of the rat sciatic nerve. Despite the evidence pointing to a role of PTN in the development of chronic pain, the role of...

Methods for reliable evaluation of spinal cord (SC) injury in rats at short periods (2 and 24 h) after lesion were tested to characterize the mechanisms implicated in primary SC damage. We measured the physiological changes occurring after several procedures for producing SC injury, with particular emphasis on sensorimotor functions. Segmental and suprasegmental reflexes were tested in 39 male ...

Neurotropin is a nonprotein extract isolated from inflamed skin of rabbits inoculated with vaccinia virus, and used for treatment of neuropathic pain. In the present study, we have determined whether neurotropin could exert antinociceptive action using the central neuropathic pain model that we recently established. Rats were randomly allocated to 3 groups: Sham group (n=20), DSP-4 [N-(-2-chlor...