Indomethacin (IND) is one of the supporting drug candidates for colonic targeting but it belongs to BCS class II category presenting a challenge in optimal at site. To overcome this challenge, we sought prepare pH-dependent soluble ternary solid dispersion (SD) IND improved solubility and dissolution rate colon without need coating. The current study focuses on preparation binary SDs API with s...

Hot melt extrusion has gained considerable attention as a novel technique for taste masking of bitter APIs. The aim of this study was to investigate whether hot melt extrusion could be used to develop taste masked formulations of isoniazid and also to evaluate and correlate different taste assessment methods Two polymers with different physico-chemical properties, Soluplus and Eudragit E-PO wer...

In this study, the effect of calcium (Ca) and erbium (Er) on microstructure, mechanical properties, corrosion behavior magnesium-zinc alloys is reported. The were prepared using disintegrated melt deposition (DMD) technique alloying additions as Zn, Ca, Mg-Er master followed by hot extrusion. Results show that addition Er has significantly reduced grain sizes Mg-Zn also when compared to pure ma...

Behaviour in a Dynamic In Vitro Dissolution Model A. Goyanes, H. Chang, A. Buanz, J. Wang, S. Gaisford, A. W. Basit University College London Purpose 3-dimensional printing (3DP) is a new technology which could potentially revolutionise the future of pharmaceutical manufacturing. In fused-deposition modelling (FDM) printing, a polymer filament is heated and extruded through a small tip and soli...

this research was conducted to study the effect of lime based flux with the composition of cao-20%caf2-8%feo on simultaneous removal of phosphorus and sulfur from hot metal. the effects of na2o and oxygen blowing were also studied. the experiments were performed using an induction furnace and hot metal produced in isfahan steel company in the temperature range 1350-1450 ºc. the results showed t...