BACKGROUND Long chain polyunsaturated fatty acids (LCPUFAs) are biologically active fatty acids which regulate placental angiogenesis, inflammation, and oxidative stress. Abnormalities in these aspects have been associated with preeclampsia (PE). Further, placenta has a heterogeneous structure with differential vascularization across different regions. We therefore hypothesize that the distribu...

The detrimental effects of active smoking upon pregnancy are well documented and unequivocal, providing a framework for investigating the effects of environmental tobacco smoke (ETS) exposure upon reproduction and development. Maternal active smoking adversely affects fetal growth and is associated with decreased BW, small for gestational age babies, preterm deliveries (especially prior to 33 w...

A 35-year-old woman with recurrent severe placenta-mediated pregnancy complications in her 2 pregnancies asks: Will low-molecular-weight heparin help prevent recurrent placenta-mediated pregnancy complications in my next pregnancy? We performed a meta-analysis of randomized controlled trials (RCTs) comparing low-molecular-weight heparin (LMWH) vs no LMWH for the prevention of recurrent placenta...

Objective:
 To relate and appraise the morphological variationsof placenta umbilical cord in normal pregnancy.
 Materials Methods:
 The study included 100 placentas which were collected from GovernmentMaternity Hospital Hashtnagri studied Anatomy department of Khyber Medical CollegePeshawar over one month duration. variations placenta, like shape, weightand attachment noted photo...

OBJECTIVE To assess the impact of controlled cord traction on the incidence of postpartum haemorrhage and other characteristics of the third stage of labour in a high resource setting. DESIGN Randomised controlled trial. SETTING Five university hospital maternity units in France. PARTICIPANTS Women aged 18 or more with a singleton fetus at 35 or more weeks' gestation and planned vaginal d...

Objective To assess the impact of controlled cord traction on the incidence of postpartum haemorrhage and other characteristics of the third stage of labour in a high resource setting. Design Randomised controlled trial. Setting Five university hospital maternity units in France. Participants Women aged 18 or more with a singleton fetus at 35 or more weeks’ gestation and planned vaginal deliver...

Diagnosing placenta percreta can be difficult. We describe a 41-year-old woman presenting at 21 weeks' gestation with intraabdominal bleeding and no signs of placental abnormality on ultrasound. The disagreement between results of the ultrasound and magnetic resonance imaging made definitive diagnosis difficult. The bleeding resolved spontaneously after a blood transfusion, and the patient was ...

Acute atherosis is unique vascular changes of the placenta associated with poor placentation. It is characterized by subendothelial lipid-filled foam cells, fibrinoid necrosis of the arterial wall, perivascular lymphocytic infiltration, and it is histologically similar to early-stage atherosclerosis. Acute atherosis is rare in normal pregnancies, but is frequently observed in non- transformed s...

In fetuses with complex congenital heart disease (CHD), impaired brain growth and development starts in utero. A interplay between heart, brain, body placenta takes place the second third trimesters of pregnancy. Altered fetal cardiovascular hemodynamics due to differnt types CHD lead altered cerebral, placental perfusion, all factors contributing maturational delay development. Impaired cerebr...

OBJECTIVE To investigate the relationship between gestational complications and high levels of maternal serum alfa-fetoprotein (MSAFP) and/or beta human chorionic gonadotropin (hCG) and to determine whether these markers are effective predictors of poor pregnancy outcomes. MATERIALS AND METHODS In this study, we enrolled a total of 679 women at 15-20 gestational weeks with MSAFP and hCG below...