Abstract Immunotherapy medicines (immune checkpoint inhibitors, ICIs) that work directly on the immune system have shown vastly increased survival for people with cancer in phases 2 and 3 clinical studies during past few years. Nevertheless, ICI treatment (irAEs) may trigger immune-related adverse effects. An underactive thyroid is among most frequent endocrine irAE, affecting about 40% of indi...

Globally, fish production in the wild is decreasing, and different aquaculture systems are presently being used for broodstock development captivity. Seasonally, raised captivity exhibit form of reproductive dysfunction at level brain-pituitary-gonad (BPG) axis. Primarily, vitellogenic completion final oocyte maturation inhibited females, males fail to spermiate spontaneously Reproductive dysfu...

background: higher risks of reproductive problems have been found in underweight and overweight women with rapid weight gain or loss but evidence is inconsistent especially in relation to the effect of age of body weight changes. objective: the aim of our study was to detect the peculiarities of menstrual function, prevalence of different types of reproductive disorders and correlations of resp...

purpose oligo/amenorrhea, as a part of the female athlete triad has adverse effects on the athlete's bone mineral density (bmd) and cardiovascular system. hypoestrogenism, due to suppression of hypothalamus-pituitary axis (hpa) as a result of energy imbalance, is the possible cause of the triad. this study was designed based on following up and reassessment of elite female athletes who were dia...

Sexual dysfunction has been reported to be common among women with epilepsy. Controlled studies, quantitative data, and investigations of potentially contributory factors, however, have been few. The purpose of this investigation was to determine if (1) sexual dysfunction is unusually common among women with partial seizures of temporal lobe origin (TLE), and (2) sexual dysfunction varies in re...

Diseases of the thyroid gland are considered one most common endocrinopathies. This is due to influence ecologically unfavorable environmental factors, bad habits, malnutrition, comorbid conditions and genetic predisposition. Determining an algorithm for diagnosing dysfunction timely detection diseases expedient relevant. The objective: analyze state spread among population Kiev region determin...

Erectile dysfunction (ED) is the inability to develop normal erection or an hardening problem at various extent that causes inability to maintain the erection for the sufficient time required for a complete sexual activity. It can be the result of neurologic, psychogenic, vascular, urogenital and hormonal abnormalities. It is reported that it affects 52-67% of men between 40 and 70 years old. N...

1. Declining sexual function is common with aging. There may be an additional decrement associated with the menopausal transition. 2. The causes of decreased sexual activity are multiple and include physiologic, psychologic, and social factors. 3. Definitions and Classification of Female Sexual Dysfunction, given by the consensus panel of the Sexual Function Health Council of the American Found...