Recent interest in bone marrow (BM) transplantation in nonconditioned or minimally conditioned recipients warrants investigation of homing patterns of transplanted hematopoietic progenitor cells (HPCs) in irradiated and nonirradiated recipients. To this end, phenotypically defined populations of BM cells were tracked in lethally irradiated or nonirradiated mice at 1, 3, 6, and 24 hours after tr...

Cancer is associated with increased fracture risk, due either to metastasis or associated osteoporosis. After a fracture, blood clots form. Because proteins of the coagulation cascade and activated platelets promote cancer development, a fracture in patients with cancer often raises the question whether it is a pathologic fracture or whether the fracture itself might promote the formation of me...

—All offshore oil and gas platforms have finite economic life spans. One of the decommissioning options for these platforms is complete removal, requiring the use of explosives to dislodge the support structure from below the seafloor. Off California, this decommissioning option would kill large numbers of platformassociated and commercially important groundfishes that inhabit the bases of the ...

The rate of reconstitution following hematopoietic stem cell (HSC) transplantation differs widely depending on the tissue source of the cells infused. To test the hypothesis that variability in engraftment kinetics is related to differences in the efficiency with which intravenously transplanted HSCs "home" to the bone marrow (BM), the homing properties of murine fetal liver (FL), adult BM, and...

Abstract Multi-homed devices such as smartphones, tablets and laptops are enabled with multiple heterogeneous interfaces available for transmission. Those can be utilized simultaneous transmission of a single TCP flow using Multipath (MPTCP). MPTCP is protocol that designed to increase end-to-end throughput reliability communications by splitting data through parallel paths. Although delay in e...

In the course of ontogeny, the homing site for the hematopoietic stem cells (HSC) moves with certain predictability from the yolk sac to the liver/spleen and then to the marrow. The pattern of this migration has thus far been established mostly on a morphologic basis. To delineate further the course of this migration and to gain insight into its possible mechanism, we used in utero transplantat...

Stem cell homing into the bone microenvironment is the first step in the initiation of marrow-derived blood cells. It is reported that human severe combined immunodeficient (SCID) repopulating cells home and accumulate rapidly, within a few hours, in the bone marrow and spleen of immunodeficient mice previously conditioned with total body irradiation. Primitive CD34(+)CD38(-/low)CXCR4(+) cells ...

BACKGROUND Ischemia-reperfusion injury (IRI) is commonly encountered after liver surgery. This study evaluated the hepatoprotective effects of topically applied adipose-derived mesenchymal stromal cells (ADMSCs) on hepatic IRI in a rat model. METHODS ADMSCs from transgenic green fluorescent protein Sprague-Dawley rats were topically applied to the liver surface of Sprague-Dawley rats after he...

Depriving homing pigeons of olfactory information by spraying an 18% zinc sulphate solution onto their olfactory ephithelium results in anosmia that persists for at least 5 days (tested using the ‘orienting response’). To study whether anosmic zinc-sulphate-treated pigeons (ZnSO4-pigeons) were able to compensate for their loss of olfactory information by using familiar landmarks, we made releas...

Abstract For sixty years we have understood that lymphocytes recirculate through blood and secondary lymphoid organs (SLO). Recently, it has been observed SLOs contain resident populations of memory T cells. Here, show conventional isolation techniques grossly underestimate the proportion SLO CD8+ RM,and cells constitute a substantial fraction regionalized immunity within LNs. We found RMare ve...