OBJECTIVES To determine the effects of heptad repeat regions (HRs) and N-linked carbohydrate sites of the Newcastle disease virus hemagglutinin-neuraminidase (HN) protein on fusion of HN and fusion (F) proteins and HN-F interaction. METHODS We mutated six 'a' residues in the HRs and four asparagines in N-linked carbohydrate sites to alanine in the HN protein. A vaccinia-T7 RNA polymerase expr...

Humanin (HN) is a recently identified endogenous peptide that protects cells against cytotoxicity induced by various stimuli. Recently, we showed that HN binds to and inhibits Bax, a proapoptotic Bcl-2 family protein, suggesting a mechanism for HN action. In this study, we identified Bim, a Bcl-2 homology 3-only member of the Bcl-2/Bax family, as an additional HN target protein. Using in vitro ...

Humanin (HN), a 24-residue peptide, was identified as a novel neuroprotective factor and shows anti-cell death activity against a wide spectrum of Alzheimer's disease (AD)-related cytotoxicities, including exposure to amyloid beta (Abeta), in vitro. We previously demonstrated that the injection of S14G-HN, a highly potent HN derivative, into brain ameliorated memory loss in an Abeta-injection m...

1.1 The classical Hurwitz space and the moduli of curves The classical Hurwitz space first appeared in the work of Clebsch [5] and Hurwitz [17] as an auxiliary object to study the moduli space of curves. Let X be a smooth projective curve of genus g over C. A rational function f : X → P of degree n is called simple if there are at least n − 1 points on X over every point of P. Such a cover has ...

Efficient assembly of enveloped viruses at the plasma membranes of virus-infected cells requires coordination between cytosolic viral components and viral integral membrane glycoproteins. As viral glycoprotein cytoplasmic domains may play a role in this coordination, we have investigated the importance of the hemagglutinin-neuraminidase (HN) protein cytoplasmic domain in the assembly of the non...

The hemagglutinin-neuraminidase (HN) glycoprotein of the paramyxovirus SV5 is a type II integral membrane protein that is expressed at the infected cell surface. The intracellular assembly and transport of HN in CV1 cells was examined using conformation-specific HN mAbs and sucrose density sedimentation analysis. HN was found to oligomerize with a t1/2 of 25-30 min and these data suggest the ol...

I described a new UUTD grading system, including HN and UD, based on magnetic resonance urography (MRU) [6] . Herein I describe a new comprehensive classification system for lower and upper urinary tract dysfunction in patients with NB ( table 1 ). In table 1 , LUTD is described according to the Guidelines of the European Association of Urology (EAU) [2] and the terminology of the International...

The hemagglutinin-neuraminidase (HN) gene sequence was determined for 16 antigenic variants of human parainfluenza virus type 3 (PIV3). The variants were selected by using monoclonal antibodies (MAbs) to the HN protein which inhibit neuraminidase, hemagglutination, or both activities. Each variant had a single-point mutation in the HN gene, coding for a single amino acid substitution in the HN ...

In this work we study elliptic divisibility sequences over finite fields. Morgan Ward in [11, 12] gave arithmetic theory of elliptic divisibility sequences. We study elliptic divisibility sequences, equivalence of these sequences and singular elliptic divisibility sequences over finite fields Fp, p > 3 is a prime. Keywords—Elliptic divisibility sequences, equivalent sequences, singular sequence...