نتایج جستجو برای: hmgb proteins

تعداد نتایج: 555827  

2017
Hao Zhou Nuan Wang Lei Xu Hongli Huang Chunyu Yu

This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. The clinical data of 92 EAS patients admitted for treatment between April, 2014 and March, 2016 were collected. These patients were randomly div...

2011
Yaseen M Arabi Mohammed Dehbi Asgar H Rishu Engin Baturcam Salim H Kahoul Riette J Brits Brintha Naidu Abderrezak Bouchama

INTRODUCTION Hyperglycemia represents an independent prognostic factor in critically ill non-diabetic patients but not in those with diabetes. In this context, there is an ongoing debate on the benefit of an intensive insulin therapy, particularly in diabetic patients. We tested the hypothesis that expression of the receptor for advanced glycation end-products (RAGE), an important signal transd...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Thiruvengadam Arumugam Vijaya Ramachandran Sobeyda B Gomez Ann M Schmidt Craig D Logsdon

PURPOSE The receptor for advanced glycation end products (RAGE) contributes to multiple pathologies, including diabetes, arthritis, neurodegenerative diseases, and cancer. Despite the obvious need, no RAGE inhibitors are in common clinical use. Therefore, we developed a novel small RAGE antagonist peptide (RAP) that blocks activation by multiple ligands. EXPERIMENTAL DESIGN RAGE and its ligan...

Journal: :International journal of clinical and experimental pathology 2015
Yao Yu Lu Yang Jinlei Lv Xu Huang Jinglin Yi Chonggang Pei Yi Shao

Diabetic Retinopathy (DR) is one of the most common complications of the late phase diabetes, and also a common cause of blindness. High mobility group box 1 (HMGB-1) is considered to be an inflammatory mediator in the late phase that promotes inflammation and neovascularization in diabetes. Therefore, this paper discussed the role of HMGB-1 in diabetic retinopathy inflammation and neovasculari...

2015
Dylan E. Lee Ryan M. Trowbridge Nagi T. Ayoub Devendra K. Agrawal

Keloids and hypertrophic scars represent excessive wound healing involving high production of collagen by skin fibroblasts. This review focuses on the role of high-mobility group box protein-1 (HMGB-1), matrix metalloproteinases (MMPs), and vitamin D in these conditions. Although the role of HMGB-1 in keloids and hypertrophic scars is unclear, the effect of HMGB-1 on fibroblasts suggests a prof...

2010
Niccolò Terrando António Rei Fidalgo Marcela Vizcaychipi Mario Cibelli Daqing Ma Claudia Monaco Marc Feldmann Mervyn Maze

INTRODUCTION The impact of pro-inflammatory cytokines on neuroinflammation and cognitive function after lipopolysaccharide (LPS) challenge remains elusive. Herein we provide evidence that there is a temporal correlation between high-mobility group box 1 (HMGB-1), microglial activation, and cognitive dysfunction. Disabling the interleukin (IL)-1 signaling pathway is sufficient to reduce inflamma...

2008
Victor Y. Stefanovsky Tom Moss

The mammalian architectural HMGB-Box transcription factor UBF is ubiquitously expressed in two variant forms as the result of a differential splicing event, that in the UBF2 deletes 37 amino acid from the second of six HMGB-boxes. Several attempts to define a function for this shorter UBF2 protein have been less than satisfactory. However, since all mammals appear to display similar levels of t...

Journal: :Respiratory Physiology & Neurobiology 2011
Frank Silva Bezerra Samuel Santos Valença Karla Maria Pereira Pires Manuella Lanzetti Wagner Alves Pimenta Aline Cunha Schmidt Luís Cristóvão Porto Walter Araujo Zin

Cigarette smoke (CS)-induced emphysema is caused by a continuous inflammatory response in the lower respiratory tract. The development of the condition is believed to be mediated by oxidant-antioxidant imbalance. This paper describes the effects of long-term CS exposure on alveolar cell recruitment, antioxidant defense systems, activity of extracellular matrix metalloelastases, expression of me...

2013
Oskar Zakiyanov Vitezslav Kriha Jan Vachek Tomas Zima Vladimir Tesar Marta Kalousova

BACKGROUND Placental growth factor (PlGF), pregnancy-associated plasma protein-A (PAPP-A), soluble receptor for advanced glycation end products (sRAGE), extracellular newly identified receptor for RAGE binding protein (EN-RAGE) and high mobility group box 1 (HMGB-1) are novel biomarkers in chronic kidney disease (CKD). However, their clinical significance in acute kidney injury (AKI) is unknown...

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