Anorectal melanoma is a rare and highly aggressive malignancy accounting for 0.4% to 1.6% of all 0.5% anorectal cancer. About 80% cases are confused with haemorrhoids, rectal polyp, ulcer or adenocarcinoma as they commonly present bleed. We herein reported case 55-year male presenting 6-months history vague abdominal pain, constipation, tenesmus, weight loss, passage blood in stool. Clinical ex...

Abstract Aims Paget’s disease of the nipple (PDN) is a rare type cancer nipple-areola complex. We examined GATA3 protein expression in PDN to determine its potential value as an adjunct marker differential diagnosis with other lesions. Methods and results Chart review documented clinicopathological data. H&E slides were re-evaluated immunohistochemistry (IHC) for was performed. Amongst 3614...

primary sarcoma of the breast is very rare and constitutes less than 1% of all breast cancers. herein, we report a case of pleomorphic rhabdomyosarcoma (prms) of the right breast in a 49-year-old female patient presented with a mass (7 cm × 6.5 cm). mammography and ultrasonography suspected a malignant lesion and a diagnosis of poorly differentiated carcinoma was made on fine needle aspiration ...

We report 2 cases of cytokeratin-20 negative neuroendocrine tumors with skin involvement that were not Merkel cell carcinoma. Patient 1. Patient 1 was a 72-year-old man with 3 asymptomatic papular, erythematous lesions measuring 2 to 3 mm in the right paranasal region (Fig. 1). The lesions had appeared 20 days earlier. One of the lesions was excised to reveal a diffuse epithelial tumor consisti...

Background:The misfolding and prion-like propagation of the protein alpha-synuclein(α-Syn) is leading molecular signature in Parkinson’s disease(PD). It has a protective role nucleus, where it recruited to DNA double-strand break sites promote damage response repair. The α-Syn also highly expressed melanoma. Elevated levels correlate with poorer survival melanoma expression required for tumor g...

Abstract Introduction/Objective Uterine leiomyosarcoma is a malignant neoplasm with three distinct histologic subtypes: spindle, epithelioid, and myxoid. Distinguishing from mesenchymal uterine neoplasms such as endometrial stromal sarcoma can be challenging they may exhibit similar histology immunohistochemical profile. In cases, molecular studies help achieve the definitive diagnosis. It has ...

A 90-year-old woman presented with 1-year history of right-sided progressive proptosis, neovascular glaucoma, blindness, and worsening ocular pain. No funduscopic examination was possible because of a corneal opacity. Head CT scan without contrast demonstrated a heterogeneous 4.1 cm (anterior-posterior) by 1.7 cm (transverse) cylindrical mass arising in the right optic nerve and extending from ...

Sir, A 13-year-old girl presented with complaints of a boggy mass on her left frontoparietal scalp since birth with thinning of the overlying hair. The lesion was first noticed at birth and gradually increased in size with age. On examination, a large (12 × 14 cm) soft to firm, bosselated, skin-colored plaque was seen involving the vertex and left frontoparietal scalp. The surface was irregular...

Spontaneous rupture of spleen due to malignant melanoma is a rare situation, with only a few case reports in the literature. This study reports a previously healthy, 30-year-old man who came with chief complaint of acute abdominal pain to emergency room. On physical examination, abdominal tenderness and guarding were detected to be coincident with hypotension. Ultrasonography revealed mild sple...