نتایج جستجو برای: histamine h3 receptor
تعداد نتایج: 614993 فیلتر نتایج به سال:
Reactive hyperemia (RH) is an abrupt blood flow increase following release from mechanical occlusion of an artery, with restoration of intra-arterial pressure. The mechanism of this postocclusion increase in blood flow in the gut is multifactorial. Relaxation of intestinal resistance vessels, observed during RH, may involve myogenic, metabolic, hormonal and neurogenic factors. Evidence exists t...
We describe the binding of [125I]iodophenpropit, the first radiolabelled histamine H3-antagonist, to ratcortex membranes. The binding of [125I]iodophenpropit was selective, saturable, readily reversible, and of high affinity (Ko-value of 0.32 nM; Bmax-value of 209 fmoVmg of protein). Specific binding at a concentration of 0.3 nM accounted for 45 to 55% of total binding. [125I]Iodophenpropit...
OBJECTIVE(S) The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on inflammatory pain. MATERIAL AND METHODS Two stainless steel guide canulas were bilaterally implanted into the PSC of anaesthetized rats. Inflammatory ...
Li, Mingkai, Jing Hu, Zhong Chen, Jia Meng, Haifang Wang, Xue Ma, and Xiaoxing Luo. Evidence for histamine as a neurotransmitter in the cardiac sympathetic nervous system. Am J Physiol Heart Circ Physiol 291: H45–H51, 2006. First published January 6, 2006; doi:10.1152/ajpheart.00939.2005.—The colocalization of histamine (HA) and norepinephrine (NE) immunoreactivities was identified within the s...
Histamine mediates its physiological function through binding to four known histamine receptors. Here, we describe the first selective antagonist of the histamine H4 receptor, the newest member of the histamine receptor family, and provide evidence that such antagonists have anti-inflammatory activity in vivo. 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine (JNJ 7777120) has a K(i) of 4...
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