background: histamine is a food-borne chemical hazard which causes scombroid poisoning. the efficiency of histamine recovery from fish is greatly influenced by selection of an appropriate extraction solvent. hence, in this study the efficiency of different extraction solvents on recovery of histamine from fresh, frozen and canned fish was evaluated. methods: fresh, frozen and canned rainbow tro...

Histamine, beta-adrenergic amines, and prostaglandins inhibited hemolytic plaque formation by splenic leukocytes from immunized mice. The same agents had previously been shown to prevent both the IgE-mediated release of histamine from human basophils and the immunologically specific cytolytic activity of murine lymphocytes, through stimulation of the production of cyclic AMP in leukocytes. We t...

This study aims to explore the role of YKL-40 on permeability vessels in mice model and HDMECs histamine induces vascular hyperpermeability. The expression a HMC-1 was detected by RT-PCR western blot. experiment divided into different concentrations (10, 100 500ng/ml) alone,different concentrations(10, 500 ng/ml) YKL-40+100 μM histamine,500ng/ml YKL-40+100μM histamine+10 loratadine,100 alone bl...

Histamine is a key mediator governing vital cellular processes in mammals beyond its decisive role in inflammation. Recent evidence implies additional actions in both eukaryotes and prokaryotes. Besides its function in host defense against bacterial infections, histamine elicits largely undefined actions in microorganisms that may contribute to bacteria-host interactions. Bacterial proliferatio...

Angiogenesis plays an important role in cancer and in many other human diseases. Vascular endothelial growth factor-A (VEGF-A), the best known angiogenic factor, was originally discovered as a potent vascular permeability factor (VPF), suggesting that other vascular permeabilizing agents, such as histamine and serotonin, might also have angiogenic activity. We recently demonstrated that, like V...

BACKGROUND Mast cell and basophiles are thought to be central to inflammation that has an allergic basis as allergens activate these cells in an IgE-dependent manner to generate mediators such as histamine, eicosanoids and cytokines. Phosphodiesterase (PDE) is known to exist as multiple molecular forms of enzyme that metabolise the second messengers. Studies of our own have shown that, of a var...

Histidine is an amino acid precursor of neuronal histamine. It is evident that peripheral injection of histidine produces effects that resemble to centrally administered histamine. The aim of the present study was to compare the effects of intracerebroventricular (ICV) injection of histamine and inraperitoneal (IP) injection of histidine on food intake in rabbits. ICV injections of histamine (1...

We studied regional changes in ventilation and aerosol deposition after histamine challenge in six patients with asthma and two with rhinitis and a history of wheezing. All were known to have bronchial hyperreactivity and all showed an increased response to histamine. Ventilation and aerosol deposition studies, using xenon-133 and an aerosol of sulphur colloid tagged with technetium 99m, were p...

The ECL cells are endocrine/paracrine cells in the acid-producing part of the stomach. They secrete histamine in response to circulating gastrin. Gastric submucosal microdialysis has been used to study ECL-cell histamine mobilization in awake rats. In the present study we assess the usefulness and limitations of the technique. Microdialysis probes were implanted in the gastric submucosa. Histol...

secretion in vivo and in vitro. The inhibitory effect of endogenous NO on stimulated acid secretion has also been demonstrated in rats. Thus, NO is generally thought to inhibit the stimulation of gastric acid secretion. On the contrary, we have demonstrated that NO has a stimulatory effect on gastric acid secretion: Sodium nitroprusside, a NO donor, increases acid secretion in isolated mouse st...