purpose: to describe the variability of ocular and systemic findings in two brothers with gaucher's disease. case report: ophthalmic, general clinical evaluation and enzymatic studies were performed in two brothers, 14 and 7 years old with gaucher’s disease. mental retardation, occipital meningomyelocele and gaucher cells in bone marrow in addition to high myopia and various fundus abnorma...

PURPOSE To determine the prevalence of myopia and ocular biometry in population-based samples of ethnic Yi and Han people living in an inland rural community in China. METHODS A random cluster sampling strategy was used to select ethnic Han and Yi adults aged 50 years or older living in Yunnan. Refractive error was determined by subjective refraction and ocular biometric parameters, including...

purpose: to determine the effect of induced myopia and hyperopia using soft contact lenses on optic disc parameters measured by fourier domain optical coherence tomography (fd-oct) in emmetropic persons. methods: in a quasi-experimental self controlled study, 57 normal emmetropic participants 18-42 years of age were studied. each subject underwent a complete ophthalmic examinations including me...

PURPOSE Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development. Among all of the muscarinic acetylcholine receptors (mAChRs), mAChR 1 (M1) was the most effective in preventing myopic eye change. Our spec...