The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of Glipizide (G) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. The release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also e...

BACKGROUND The combination of metformin and a sulphonylurea has been recommended for treatment of type 2 diabetes. A, scored, breakable, extended release, once daily fixed dose combination (FDC) of gliclazide and metformin is available in India. OBJECTIVE To assess the initial blood glucose lowering efficacy, glycemic control and patient acceptability of the fixed dose combination of original...

PURPOSE The present investigation is to study the influence of metronidazole and tinidazole on the usefulness of guar gum, a colon-specific drug carrier based on the metabolic activity of colonic bacteria, using matrix tablets of albendazole (containing 20% of guar gum) as a model formulation. METHODS The matrix tablets of albendazole were subjected to in vitro drug release studies in simulat...

   Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...

FocalinTM XR (dexmethylphenidate hydrochloride) extended-release capsules is an extended-release formulation of dexmethylphenidate with a bi-modal release profile. FocalinXR uses the proprietary SODASTM (Spheroidal Oral Drug Absorption System) technology. Each bead-filled Focalin XR capsule contains half the dose as immediate-release beads and half as enteric-coated, delayed-release beads, thus...

In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan derivatives have been studied as permeation enhancer in free soluble form and as nanoparticulate systems. The aim of the current work wa...

Orodispersible tablets (ODT) of levocetirizine was prepared using natural polysaccharides ipomoea batatas starch, amorphophallus campanulatus starch and their modified form by direct compression method and evaluated for their superdisintegrant activity. Levocetirizine dihydrochloride was used as a model drug. The prepared formulations were compared with synthetic superdisintegrants such as cros...