Rapid growth in size and complexity of biological data sets has led to the 'Big Data to Knowledge' challenge. We develop advanced data integration methods for multi-level analysis of genomic, transcriptomic, ribosomal profiling, proteomic and fluxomic data. First, we show that pairwise integration of primary omics data reveals regularities that tie cellular processes together in Escherichia col...

This article serves as an introduction to this special issue as well as a self-standing contribution. Using the lens of technology, we situate European integration (typically viewed as a political process) as an emergent outcome of a process of linking and delinking of infrastructures, as well as the circulation and appropriation of artefacts, systems and knowledge. These processes carried, sha...

Experimental data in life sciences, created with today's sequencing techniques, accumulate rapidly in different formats and data sources, leaving facts and knowledge on observed phenomena hidden and unreachable to researchers. The "big data" problem can be seen from various aspects. In this paper, we pointed out to those that can be solved with some sort of data integration. Combining data from...

Disconnects and defects in care – such as duplication, poor integration between services or avoidable adverse events – are costly to the health system and potentially harmful to patients and families. For patients living with multiple chronic conditions, such disconnects can be particularly detrimental. Lean is an approach to optimizing value by reducing waste (eg, duplication and defects) and ...

We present a new approach for discovering hidden relationships in sparse bipartite data by identifying large, dense biclusters in the corresponding matrix. We motivate a new class of metrics to measure the quality of a bicluster partition, and compare them to existing metrics. We then present a heuristic algorithm that efficiently searches the space of possible co-clusterings for one which maxi...

Software integration is one of the major needs as well as cost driving factors in the software industry today. Still, very few established methodologies exist, especially those addressing integration with respect to non-functional properties. Industry studies show that disregarded and hidden non-functional incompatibilities between systems and their interfaces are the constant source of errors ...

T his study examines the effect of oil fluctuation export earnings on government income and expenditure in Nigeria using a time series data from 1986 to 2015. The study utilized co-integration techniques and ordinary least square as the methods of analyses. The co-integration tests indicate the existence of a long-run equilibrium relationship between oil...