نتایج جستجو برای: hey2

تعداد نتایج: 190  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Hiroshi Doi Tatsuya Iso Miki Yamazaki Hideo Akiyama Hiroyoshi Kanai Hiroko Sato Keiko Kawai-Kowase Toru Tanaka Toshitaka Maeno Ei-ichi Okamoto Masashi Arai Larry Kedes Masahiko Kurabayashi

OBJECTIVE Myocardin is a coactivator of serum response factor (SRF) required for vascular smooth muscle cell (VSMC) differentiation. HERP1 is a transcriptional repressor, which is abundantly expressed in vascular system and is known to function as a target gene of Notch. However, the role of HERP1 in the pathogenesis of vascular lesions remains unknown. The present study characterizes the expre...

2012
Mian Xie Ming Liu Chao-Sheng He

BACKGROUND Sirtuin 1 (SIRT1) acts as a key regulator of vascular endothelial homeostasis, angiogenesis, and endothelial dysfunction. However, the underlying mechanism for SIRT1-mediated lung carcinoma angiogenesis remains unknown. Herein, we report that the nicotinamide adenine dinucleotide 1 (NAD1)-dependent deacetylase SIRT1 can function as an intrinsic negative modulator of Delta-like ligand...

Journal: :Blood 2006
Cassin Kimmel Williams Ji-Liang Li Matilde Murga Adrian L Harris Giovanna Tosato

Delta-like 4 (Dll4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in the developing endothelium and in some tumor endothelium, and it is induced by vascular endothelial growth factor (VEGF)-A and hypoxia. Gene targeting studies have shown that Dll4 is required for normal embryonic vascular remodeling, but the mechanisms underlying Dll4 regulatory functions are current...

2010
Yoshimi Tokuzawa Ken Yagi Yzumi Yamashita Yutaka Nakachi Itoshi Nikaido Hidemasa Bono Yuichi Ninomiya Yukiko Kanesaki-Yatsuka Masumi Akita Hiromi Motegi Shigeharu Wakana Tetsuo Noda Fred Sablitzky Shigeki Arai Riki Kurokawa Toru Fukuda Takenobu Katagiri Christian Schönbach Tatsuo Suda Yosuke Mizuno Yasushi Okazaki

Excessive accumulation of bone marrow adipocytes observed in senile osteoporosis or age-related osteopenia is caused by the unbalanced differentiation of MSCs into bone marrow adipocytes or osteoblasts. Several transcription factors are known to regulate the balance between adipocyte and osteoblast differentiation. However, the molecular mechanisms that regulate the balance between adipocyte an...

2013
Sara Tesfazghi Jacob Eide Ajitha Dammalapati Colin Korlesky Thomas P Wyche Tim S Bugni Herbert Chen Renata Jaskula-Sztul

Medullary thyroid cancer (MTC) is an aggressive neuroendocrine tumor (NET). Previous research has shown that activation of Notch signaling has a tumor suppressor role in NETs. The potential therapeutic effect of thiocoraline on the activation of the Notch pathway in an MTC cell line (TT) was investigated. Thiocoraline was isolated from a marine bacterium Verrucosispora sp. MTT assay (3-[4, 5-di...

Journal: :Hypertension 2006
Hironori Nakagami Namika Nakagawa Yasushi Takeya Katsunobu Kashiwagi Chisato Ishida Shin-ichiro Hayashi Motokuni Aoki Kunio Matsumoto Toshikazu Nakamura Toshio Ogihara Ryuichi Morishita

Embryonic stem (ES) cells are highlighted as promising cell sources for regenerative medicine. Here, we focused on providing the platform that forced ES cells to reproduce the vascular organization process, leading to efficiency and safety evaluation as preclinical testing of biological agents. Murine ES cell-derived embryoid bodies on matrigel, but not collagen or gelatin, could be differentia...

2005
Ryuichi Kitamura Yusak O. Susilo

Does a stop a commuter makes on the way to or from work adversely affect peak-period traffic? This question is addressed by examining the effects of stops made as part of commute journeys upon daily, as well as peak-period, travel time and distance, using a six-week travel diary data set from Germany. Increments in travel time and distance due to stops made in commute journeys are evaluated and...

2011
Jeffrey C. Zemla Volkan Ustun Michael D. Byrne Alex Kirlik Kenyon Riddle

The Next Generation Air Transportation System (NextGen) seeks to reduce gridlock at airports by, among other things, creating a more efficient surface taxi management system. Addressing this situation creates a difficult evaluation problem; how can new scheduling methods be tested? Present methods generally involve either expensive human-in-the-loop experiments or computer simulations that do n...

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