It is generally believed that gastric emptying of solids is regulated by a coordinated motor pattern between the antrum and pylorus. We studied the role of the vagus nerve in mediating postprandial coordination between the antrum and pylorus. Force transducers were implanted on the serosal surface of the body, antrum, pylorus, and duodenum in seven dogs. Dogs were given either a solid or a liqu...

We investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arterial pressures and on pressor reactivity in 3-month-old male spontaneously hypertensive rats (SHR). Arterial blood pressure (BP) and pressor reactivity to phenylephrine (PHE) were investigated before and after 0.18 μg/kg ouabain administration (N = 6). The influence of hexamethonium (N = 6), canr...

Acute intravenous Tempol reduces mean arterial pressure (MAP) and heart rate (HR) in spontaneously hypertensive rats. We investigated the hypothesis that the antihypertensive action depends on generation of hydrogen peroxide, activation of heme oxygenase, glutathione peroxidase or potassium conductances, nitric oxide synthase, and/or the peripheral or central sympathetic nervous systems (SNSs)....

The renal blood vessels were studied for a cholinergic determinant of their response to renal nerve stimulation. In dogs anesthetized with morphine and chloralose, control values were: mean aortic blood pressure 147 ± 4 mm Hg, renal blood flow 257 ± 12 ml/min. Acetylcholine (ACh) in 1-, 10and 100-^tg doses (all drugs given into the renal artery) increased renal blood flow, whereas 1000 fig of A...

CAREN,JEFFREY F., JAMES H. MEYER, AND MORTON I. GROSSMAN. Canine intestinal secretion during and after rapid distention of the small bowel. Am. J. Physiol. 227( 1) : 183-l 88. 1974.-In dogs with Thiry-Vella loops of jejunum and ileum, intestinal secretion was studied during and after ileal loop distention with latex balloons. Intraluminal pressures during distentions, as well as fluid outputs a...