Diffusion of transmembrane and peripheral membrane-bound proteins within the crowded cellular membrane environment is essential to diverse biological processes including cellular signaling, endocytosis, and motility. Nonetheless we presently lack a detailed understanding of the influence of physiological levels of crowding on membrane protein diffusion. Utilizing quantitative in vitro measureme...

TDP-43 is a highly conserved nuclear factor of yet unknown function that binds to ug-repeated sequences and is responsible for cystic fibrosis transmembrane conductance regulator exon 9 splicing inhibition. We have analyzed TDP-43 interactions with other splicing factors and identified the critical regions for the protein/protein recognition events that determine this biological function. We sh...

the polysulfone-based membrane has been used in hemodialysis (hd) and it is continuously developed to maintain its sustainability on the subject of biocompatibility. during the polysulfone-based membrane development, several parameters should be considered to improve the membrane performances, such as excellent biocompatibility, appropriate ultrafiltration rate, and effective clearance of the t...

Abstract Bioinspired nanofluidic devices have drawn increasing global interest due to their giant applicable potential in a wide range of fields. By mimicking biological prototype, it is expected achieve high energy conversion efficiency and tunable ion transport. However, the low osmotic efficiency, weak transport capability poor mechanical performance limit practical application. We designed ...

poly (n-bromosuccinimide) (pnbs) as a mild, efficient, non-acidic, polymeric and heterogeneous catalyst was applied for simple conversion of epoxides into thiiranes by treatment with kscn or (nh2)2cs at room temperature. aliphatic and aromatic epoxides converted into their corresponding thiiranes under mild conditions. all reactions proceeded in short reaction times and afforded the correspondi...

in this research, zeolite a was synthesized from waste porcelain and cds nano-particles were doped in zeolite framework by a precipitation after an ion exchanging process. all raw and modified samples were characterized by ft-ir, xrd and sem methods. primary experiments showed that the good efficiency of loaded nano cds onto the zeolite a for photodecomposition of dimethyldisulfide (dmds) under...

background:  radiochromic film is used for radiation dose measurement, xr-rv3 is used in fluoroscopy and ebt2 film in radiation therapy. the aim was to determine if the dosimetric properties of these two films are comparable in megavolt photon beams. materials and methods: comparison measurements included: calibration curves, heterogeneous phantom dose profiles, and nasopharynx dose distributio...

in the present study, the synthesis of diethylene triamine supported on cellulose biopolymer as a biodegradable solid basic heterogeneous catalyst was suggested. then, the applicability of the synthesized catalyst cellulose bonded n-propyl diethylene triamine (cbpdeta) was tested for the synthesis of oxindole derivatives, an important class of potentially bioactive compounds. a various series o...