A detailed quantitative analysis was made of the lungs from 8 infants dying with bilateral renal agenesis or dysplasia. Total lung volume was reduced in all cases, particularly in those with renal agenesis. In both groups there was a reduction in number of airway generations, indicating interference with development at between 12 and 16 weeks' gestation. The alveoli in each acinus were reduced ...

vagina is a rare disease entity that is often accompanied by ipsilateral renal agenesis. It was recognized as early as 1922 (1) and is sometimes referred to as HerlynWerner-Wunderlich (HWW) syndrome (2, 3). The association of renal agenesis with ipsilateral blind hemivagina was reported as Herlyn-Werner syndrome in 1971 (4), while the association of renal aplasia, bicornuate uterus with isolate...

Wnt signaling regulates embryonic pattern formation and morphogenesis of most organs. Aberrations of regulation of Wnt signaling may lead to cancer. Here, we have used positional cloning to identify the causative mutation in a Finnish family in which severe permanent tooth agenesis (oligodontia) and colorectal neoplasia segregate with dominant inheritance. Eleven members of the family lacked at...

The developmental origin of arsenate-induced renal agenesis was investigated. Pregnant Wistar rats were each injected once ip with 45 mgkg sodium arsenate a t day 10 (sperm day = day 0). Pregnancy was terminated a t various times following injection and the embryos recovered and serially sectioned. Renal agenesis resulted when the mesonephric duct failed to give rise to a ureteric bud with subs...

Agenesis of the inferior vena cava (IVC) is a rare anomaly which can be identified as incidental finding or can be associated with iliofemoral vein thrombosis. IVC agenesis has a known association with renal anomalies which are mainly confined to the right kidney. We describe a case of a 14-year-old male who presented with left leg swelling and pain. Ultrasonography confirmed the presence of le...

Renal clear cell carcinomas represent about 3% of all visceral cancers and account for approximately 85% of renal cancers in adults. Environmental and genetic factors are involved in the development of renal cancer. Although to date there are 19 hereditary syndromes described in which renal cell cancer may occur, only four syndromes with an unequivocal genetic predisposition to renal cell carci...

Obstructed hemi-vagina and ipsilateral renal agenesis (OHVIRA) syndrome is a complex of Müllerian Wolffian duct anomalies constituted by obstructed that may form hematocolpos with anomaly different degrees didelphic uterine anomalies. Due to the obstructive reproductive tract, endometriosis differing severities be common complication OHVIRA syndrome. Here, we report three women showed clinical ...

Caudal regression syndrome (CRS) is a rare congenital disorder characterized by developmental abnormalities of caudal spinal segments. To date, the etiology of CRS is unclear; sporadic cases are strongly associated with maternal diabetes, while familiar recurrence is infrequent. We describe in detail the prenatal clinical and sonographic findings of a recently described hereditary caudal regres...

We aimed to discuss the prenatal diagnosis and pathological features of sirenomelia, and to review current embryogenic theories. We observed two sirenomelic fetuses that were at the 19th and 16th gestational week respectively. In the former, transvaginal ultrasound revealed severe oligohydramnios and internal abortion, whereas bilateral renal agenesis, absence of a normally tapered lumbosacral ...

A rare case of seminal vesicle cyst associated with ipsilateral renal agenesis is reported. The role of ultrasonography and computed tomography in diagnosis and management is discussed. Congenital malformations of the seminal vesicle are most uncommon and most of them are cystic malformation. Approximately two thirds of them are associated with ipsilateral renal agenesis, since both the uretera...