Human epidermal growth factor receptor-2 (HER 2) positive breast cancers represent a highly aggressive cancer subtype and are associated witha worse prognosis. They tend to be more with lower survival rates but better prognosis than the triple-negative subtype.

Overexpression of the epidermal growth factor receptor family member Her-2/neu in breast cancer is associated with poor prognosis. With evidence accumulating for a chemopreventive role of green tea polyphenols, the effects of epigallocatechin-3 gallate (EGCG) on Her-2/neu-overexpressing breast cancer cells were examined. EGCG inhibited mouse mammary tumor virus (MMTV)-Her-2/neu NF639 cell growt...

Two-thirds of all women who develop breast cancer each year live in Asia. In many countries, including Bangladesh, there are few data on the pathological characteristics of breast tumours. The objectives of this study were a) to describe the estrogen receptor (ER), progesterone receptor (PR), and the expression of Her-2/neu oncogene expression status in a large series of breast cancers occurrin...

INTRODUCTION Approximately 25-30% of breast cancers are assumed to be HER-2/neu positive. It is well known that HER-2/neu-positive cancers after treatment with trastuzumab can become HER-2/neu negative. Change in HER-2/neu status from negative to positive following treatment has not been well studied. We describe a patient with inflammatory breast cancer who was initially HER-2/neu negative but...

Background & objective: Globally, breast cancer is the most common malignancy among females. Prohibition (PHB)-I, a homologous protein, was initially introduced as a suppressor gene for amplification process. Further, the protein has a key role in the cell cycle and is capable of inhibiting DNA transcription in many cell types. Therefore, its possible role in different...

BACKGROUND Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology. The majority of synovial sarcomas harbor a specific chromosomal translocation in which the proximal portion of the SYT gene at chromosome 18q11 is fused to the distal portion of one of several duplicated SSX genes (most notably SSX1 and SSX2) at chromosome...

S'Ve PictS Neuter tells her story in simple yet arresting language, giving a very comprehensive des UI~k man ̂ euter> who was her teacher, her colleague, and finally her husband. Po\ver Qp ? .^'m as an extraordinarily dynamic person, with an unshakable belief in the Hany 0r sP'r'1 over matter. His enthusiasm attracted large numbers of people to him, ^ey?te th ? ^ were prepared to withstand the t...

This paper investigates how professional workers’ willingness to act with interpersonal sensitivity is influenced by the gender and power of their interaction partners. We call into question the idea that mixed-gender interactions involve more interpersonal sensitivity than all-male interactions primarily because women demonstrate more interpersonal sensitivity than do men. Rather, we argue tha...

This editorial comments on the manuscript reported by Bergqvist et al. [1] who have investigated real-time PCR (RT-PCR) and microarray-based RNA expression (RNA-EP) as alternative strategies to immunohistochemistry (IHC) and in situ hybridization (ISH) for HER-2 testing in breast cancer patients. Bergqvist et al. [1] have compared the performance of ÔstandardÕ and ÔnewÕ HER-2 testing tools in a...