BACKGROUND Schistosoma mansoni and malaria infections are often endemic in the same communities in sub-Saharan Africa, and both have pathological effects on the liver and the spleen. Hepatosplenomegaly associated with S. mansoni is exacerbated in children with relatively high exposure to malaria. Treatment with praziquantel reduces the degree of hepatosplenomegaly, but the condition does not co...

hemophagocytic syndrome (hps) is an uncommon manifestation in systemic lupus erythematosus (sle). clinical features of hps include fever, pancytopenia, abnormal liver enzyme, hepatosplenomegaly, lymphadenopathy, and coagulation disorder. hps comprises primary and reactive forms. herein, we describe a case of untreated sle with hps as one of the first manifestations of systemic lupus.

A sibship is described in which at least two brothers suffer from a unique disorder characterised by ichthyosis, hepatosplenomegaly, and late onset cerebellar ataxia. The clinical features and investigations are described. No metabolic abnormality has been found so far.

Sarcoidosis is a multisystem inflammatory disorder of unknown aetiology affecting wide range organs and characterised by the presence noncaseating granulomas. It has rarely been reported in Sri Lanka. This case describes 36-year-old male presenting with loss weight despite preserved appetite. He had evidence sarcoidosis pulmonary, lymph node, eye, hepatosplenomegaly, thyroid parotid gland invol...

In this case we discussed with a hemaphagocytic syndrome in patient who was investigated for jaundice. Hemophagocytic syndrome; fever, hypertriglyceridemia, hepatosplenomegaly, bone marrow involvement is multisystemic disease.This due to excess cytokines released from the cells.Hemophagocytic syndrome, can occur as familial or sporadic disorder, and it be triggered by variety of events that dis...

autoimmune lymphoproliferative syndrome (alps) is a rare, inherited disorder of immune dysregulation secondary to defective lymphocyte apoptosis. this leads to uninhibited proliferation of lymphoid tissue manifesting with lymphadenopathy, hepatosplenomegaly, autoimmune cytopenia, and an increased risk of lymphoid malignancy. we report a 2 year old boy with fever, generalized lymphadenopathy, he...

introduction h syndrome (omim 612391) is an autosomal recessive disease with some features such as hyperpigmentation, hypertrichosis, heart anomalies, hepatosplenomegaly, hearing deficit, hypogonadism, short stature, flexion contracture of fingers and toes and hypertriglyceridemia. case presentation a 17-year-old boy with hyperpigmented, hypertrichotic and indurated seborrheic keratosis-like cu...

A male neonate was born to a 35-year-old mother at an outside hospital at 39 1/7 weeks gestation via emergency cesarean section due to decreased fetal movements. The infant had respiratory distress secondary to meconium aspiration and was noted to have a large, distended abdomen at birth. Subsequent ultrasound confirmed hepatosplenomegaly with no evidence of liver mass or ascites. By report, al...

1 of 2 DESCRIPTION An 18-year-old man was admitted to our hospital with fever and generalised lymphadenopathy in October 2010. One month prior to admission, a submaxillary nodule appeared, with gradually progression to nodes involving the entire body. His medical history was unremarkable, and he was not receiving any medication. Physiological parameters were: body temperature, 37.7°C; heart rat...