Qilian Huaji Decoction (QLHJD) is a mixture of 13 herbs. The aim this study to observe the efficacy QLHJD against hepatocellular carcinoma (HCC). H22 transplanted mouse models were established explore effect on HCC in vivo. QLHJD-containing serum (QCS) was prepared using traditional Chinese medicine pharmacology methods. After QCS treatment, cell proliferation, cycle and apoptosis HepG2 cells a...

Abstract Hepatitis B–associated hepatocellular carcinoma (HCC) is often accompanied by severe vascular invasion and portal vein tumor thrombus, leading to a poor prognosis. However, the underlying mechanism of this disease remains obscure. In study, we demonstrate that hepatitis B virus (HBV)–encoded gene HBx induces high IL8 production through MEK–ERK signal activation, enhanced endothelial pe...

Exosomes are small membranous vesicles about 30~100 nm in diameter and formed from inward budding of the limiting membrane of multi-vesicular bodies (MVB). Exosomes are secreted by most cell types (including hepatocellular carcinoma cells) into the extracellular environment and can be isolated from various body fluids. Exosomes have broad biological function through delivering contained molecul...

Table S1 : Human gene sets retrieved from published experiments and used to determine gene sets detected in HepG2 cells (Full), liver (set 1) or deregulated in hepatocellular carcinoma HCC (set2). 20839 4918 806 Full Liver (set 1) HCC (set 2)

Contrast-enhanced ultrasound (CEUS) and super-resolution (US) are novel technologies for differentiating hepatic masses including hepatocellular carcinoma (HCC). Kupffer-phase imaging on Sonazoid CEUS can increase the diagnostic sensitivity HCC, facilitates early identification treatment of HCC. On other hand, US depict intratumoral vascularity without contrast enhancement, its performance iden...

Abstract In China, hepatocellular carcinoma (HCC) is considered a malignant tumor with poor prognosis, frequent metastasis, and high relapse rate. Telocytes (TCs) participate in tumorigenic, invasive, migratory processes by secreting functional proteins transmitting cell-to-cell information, but their functions HCC are still unknown. TC counts MMP9 expression liver cancer tissues were measured ...

Thrombin has been recently demonstrated to promote hepatocellular carcinoma (HCC) cell migration by activation of the proteinase-activated receptor (PAR) subtypes PAR1 and PAR4 suggesting a role of these proteinase-receptor systems in HCC progression. In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), the major polyphenolic compound of green tea on thrombin-PAR1...

Hepatocellular carcinoma (HCC) is the most prevalent primary liver malignancy worldwide and associated with a poor prognosis. Sophisticated molecular mechanisms biological characteristics need to be explored gain better understanding of HCC. The role metabolites in cancer immunometabolism has been widely recognized as hallmark tumor microenvironment (TME). Recent studies have focused on that ar...

DNA methyltransferase 3B (DNMT3B), one of methyltransferases has many roles in methylation and cancer pathogenesis. However, its clinical prognostic value was not studied hepatocellular carcinoma (HCC). In this study, we analyzed DNMT3B expression HCC by public big data, The Cancer Genome Atlas. Primary data about total 360 were downloaded clinicopathological implication analyzed. M stage (p = ...

BACKGROUND CENP-E, one of spindle checkpoint proteins, plays a crucial role in the function of spindle checkpoint. Once CENP-E expression was interrupted, the chromosomes can not separate procedurally, and may result in aneuploidy which is a hallmark of most solid cancers, such as hepatocellular carcinoma (HCC). We investigate the expression of CENP-E in human hepatocellular carcinoma,. and ana...