Tumor-associated macrophages, crucial components of the microenvironment in hepatocellular carcinoma, hamper anti-cancer immune responses. The aim of the present study was to investigate the effect of sorafenib on the formation of the tumor microenvironment, especially the relationship between polarized macrophages and hepatocytes. Macrophage infiltration was reduced in patients with hepatocell...

Aberrant activation of the Notch signaling pathway is implicated in many solid tumors, including hepatocellular carcinoma, indicating a potential use of Notch inhibitors for treatment. In this study, we investigated the antitumor and antimetastasis efficacy of the novel Notch inhibitor (γ-secretase inhibitor) PF-03084014 in hepatocellular carcinoma. Hepatocellular carcinoma spherical cells (ste...

The study, published in the Journal of Vascular and Interventional Radiology, was focused on investigating TACE with drug-eluting beads (Biocompatibles) in patients with Barcelona Clinic Liver Cancer (BCLC) C stage hepatocellular carcinoma. The recommended treatment for advanced stage hepatocellular carcinoma was systemic therapy. The authors noted that, until the SHARP (Sorafenib hepatocellula...

OBJECTIVE To investigate immunohistochemical markers of angiogenesis and their association with pathological prognostic features in hepatocellular carcinoma and cirrhotic liver. METHODS Vascular endothelial growth factor, CD105, and cyclooxygenase-2 were immunohistochemically detected in 52 hepatocellular carcinoma tissue samples and 48 cirrhotic liver tissue samples. Semiquantitative measure...

Chemoresistance is one of the major obstacles in systemic chemotherapy and targeted therapy for patients with advanced hepatocellular carcinoma. To identify novel chemoresistance-associated targets in hepatocellular carcinoma, chemoresistant hepatocellular carcinoma cell lines were established. By comparing the global gene expression profiles between chemoresistant and chemosensitive cell lines...

Chemoresistance is one of the major obstacles in systemic chemotherapy and targeted therapy for patients with advanced hepatocellular carcinoma. To identify novel chemoresistance-associated targets in hepatocellular carcinoma, chemoresistant hepatocellular carcinoma cell lines were established. By comparing the global gene expression profiles between chemoresistant and chemosensitive cell lines...

A nanoparticle-based formulation of sorafenib (NP-sfb) significantly inhibited hepatocellular carcinoma by suppressing angiogenesis and promoting cytotoxic T lymphocyte infiltration.

INTRODUCTION Hepatocellular carcinoma is an aggressive malignant tumor with high lethality. AIM To review diagnosis and management of hepatocellular carcinoma. METHODS Literature review using web databases Medline/PubMed. RESULTS Hepatocellular carcinoma is a common complication of hepatic cirrhosis. Chronic viral hepatitis B and C also constitute as risk factors for its development. In p...

BACKGROUND Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma. This population-based study aimed to investigate whether prevention of hepatocellular carcinoma by the universal Taiwanese HBV vaccine program, launched in July 1984, has extended beyond childhood and to identify the predictors of hepatocellular carcinoma for vaccinated birth cohorts. METHODS Data on 19...

introduction: recently, due to the special characteristics of 166ho and chitosan, 166ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. this complex has been lately prepared with high radiochemical purity in our lab. the preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and normal tissues before...