background: hepatitis e virus is an enterically transmitted virus that is endemic in south asia and this virus is one of the most important cause of acute hepatitis in this region. although hepatitis e virus (hev) is not a leading cause for chronic hepatitis, the role of hev in exacerbation of chronic liver disease is certain. materials and methods: 100 cirrhotic cases (50 hepatitis b and 50 he...

background and objective: although transfusion therapy has lead to great improvement in longevity for hemophiliacs, but there have been tragic setbacks especially from transmission of human immunodeficiency virus (hiv) and hepatitis c virus (hcv) .hiv was reported to increase the rate of hcv-related liver failure by 4.2 times. in this study, we aimed to determine the seroprevalence of hiv and h...

conclusions the most frequent subtypes of hcv in iran were 1a, 3a and 1b, respectively. this frequency differed in various provinces of iran and fluctuated with time. it is important to determine the distribution of hcv genotypes in different geographical areas and its trend with time for epidemiological and patients’ management purposes. objectives the aim of this study was to estimate the ove...

background hepatitis c virus (hcv) is the major cause of chronic liver disease. hcv is a single stranded positive sense rna of approximately 9.6 kb. because of high conservativeness of 5΄untranslated region of hcv genome, it is widely used for virus genotyping. different methods are used for the virus genotyping, but all involve some difficulties. objectives the aim of the present study was to ...

conclusions this study can serve as a fundamental experiment for the construction of a ns3/ns4a eukaryotic expression vector and its expression in mammalian cells. further research is underway to evaluate the fragment immunogenicity in lab animal models. results the results showed that the fragment was successfully amplified and cloned into a eukaryotic expression vector. sequencing and enzyme ...

the patient was infected with hcv subtype 6a. prior to this case, there have been no previous reports on the isolation of this genotype/subtype from any other iranian patient. previous epidemiological studies provide valuable information about the distribution patterns of different hcv genotypes. however, infection with genotypes other than common ones should be flagged by specialists and diagn...

Hepatitis C virus infection is a frequent clinical problem in patients on dialysis and renal transplant recipients. The local prevalence rates of hepatitis C virus infection in patients on peritoneal dialysis, hemodialysis, or after kidney transplantation are 2%, 9%, and 6%, respectively. Conventional diagnosis of hepatitis C virus infection is by anti-hepatitis C virus immunoassays. However, u...